4.5 Article

Domino/Cascade and Multicomponent Reactions for the Synthesis of Thiazole Derivatives

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Synthetic and Medicinal Perspective of Fused-Thiazoles as Anticancer Agents

Swati Pawar et al.

Summary: Cancer is the second leading cause of human mortality after cardiovascular disease, with symptoms mainly depending on the specific type such as liver, lung, stomach, breast, and colon cancer being the most common. It is characterized by uncontrolled growth of malignant cells arising from abnormal growth in normal cells, resulting in a change in cell proliferation and differentiation mechanism.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents

Ibrahim S. Alkhaibari et al.

Summary: Synthesized fused-thiazole derivatives of nootkatone showed potent antimicrobial activity against Staphylococcus aureus and Enterococcus faecium, while being non-toxic to human cancer cell lines.

CHEMMEDCHEM (2021)

Review Biochemistry & Molecular Biology

Thiazole Ring-A Biologically Active Scaffold

Anthi Petrou et al.

Summary: Thiazole is a valuable pharmacophore nucleus with a wide range of biological activities, including antioxidant, analgesic, antimicrobial, antihypertensive, anti-inflammatory, and antipsychotic properties. Recent literature review identified and critically analyzed nearly 124 research articles on the synthesis and biological activities of thiazoles derivatives in the past 5 years.

MOLECULES (2021)

Article Multidisciplinary Sciences

Antimelanoma activities of chimeric thiazole-androstenone derivatives

Steven A. Chambers et al.

Summary: The discovery of chimeric anti-melanoma agents with potent growth suppressor effects on melanoma cells was reported. These agents induced cell apoptosis through multiple pathways and showed greater cytotoxicity to melanoma cells compared to the commonly used agent dacarbazine.

ROYAL SOCIETY OPEN SCIENCE (2021)

Review Physiology

Mirabegron: The most promising adipose tissue beiging agent

Jocelyn S. Bel et al.

Summary: Accumulation of white adipose tissue contributes to the obesity epidemic, but activating beige adipose tissue may help in treating metabolic disorders like obesity and type 2 diabetes. Recent research has shown the potential of beta 3AR agonist, mirabegron, in stimulating beiging in adipose tissue, indicating a promising treatment option for metabolic disorders. Studies have also demonstrated that mirabegron has positive metabolic effects on adipokines, glucose metabolism, and lipid droplet size, making it a safer and more direct alternative to other methods like intermittent cold exposure and exercise-induced beiging.

PHYSIOLOGICAL REPORTS (2021)

Article Chemistry, Multidisciplinary

Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery

Rawan Alnufaie et al.

Summary: A library of bioactive molecules was synthesized efficiently using environmentally friendly solvent acetic acid, resulting in the creation of novel fused-thiazole derivatives. Experimental results showed that some of these compounds exhibited potent growth inhibition against cancer cell lines.

NEW JOURNAL OF CHEMISTRY (2021)

Review Endocrinology & Metabolism

Effect of Mirabegron on the Body's Exercise Capacity: A Review

Kamil Leis et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

Review Chemistry, Medicinal

2,4,5-Trisubstituted Thiazole: A Privileged Scaffold in Drug Design and Activity Improvement

Zhen Zhang et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

Article Chemistry, Organic

Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides

Tianzi Dai et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Multicomponent synthesis of diphenyl-1,3-thiazole-barbituric acid hybrids and their fluorescence property studies

Alok Mahata et al.

NEW JOURNAL OF CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Enzymatic Cascade Reactions in Biosynthesis

Christopher T. Walsh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Medicinal

Recent advances of thiazole hybrids in biological applications

Mehmet Gumus et al.

FUTURE MEDICINAL CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

Acetic acid mediated regioselective synthesis of 2,4,5-trisubstituted thiazoles by a domino multicomponent reaction

Mohit Saroha et al.

NEW JOURNAL OF CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

Four-component thiazole formation from simple chemicals under metal-free conditions

Jingjing Jiang et al.

GREEN CHEMISTRY (2019)

Article Chemistry, Organic

Real Multicomponent Reactions: Synthesis of Highly Substituted 2-Aminothiazoles

Frank Richter et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Article Chemistry, Organic

Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents

Mohamad Akbar Ali et al.

ORGANIC LETTERS (2018)

Review Urology & Nephrology

Mirabegron, alone and in combination, in the treatment of overactive bladder: real-world evidence and experience

Sara J. Allison et al.

THERAPEUTIC ADVANCES IN UROLOGY (2018)

Review Chemistry, Organic

Biological Potential of Thiazole Derivatives of Synthetic Origin

Raghav Mishra et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Hexafluoroisopropanol mediated benign synthesis of 2H-pyrido[1,2-a]pyrimidin-2-ones by using a domino protocol

Zakeyah Alsharif et al.

NEW JOURNAL OF CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Modular synthesis of thiazoline and thiazole derivatives by using a cascade protocol

Zakeyah A. Alsharif et al.

RSC ADVANCES (2017)

Article Multidisciplinary Sciences

Hexafluoroisopropyl alcohol mediated synthesis of 2,3-dihydro-4H-pyrido[1,2-a] pyrimidin-4-ones

Mohammad A. Alam et al.

SCIENTIFIC REPORTS (2016)

Review Chemistry, Medicinal

Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery

Adile Ayati et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Evaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder

Roberto Mandrioli et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2015)

Article Chemistry, Multidisciplinary

Domino reactions: concepts for efficient organic synthesis

Svetlana Borukhova

Green Processing and Synthesis (2014)

Article Chemistry, Medicinal

Synthesis and evaluation of p-N,N-dialkyl substituted chalcones as anti-cancer agents

Grady Nelson et al.

MEDICINAL CHEMISTRY RESEARCH (2013)