相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
Timothy H. Tran et al.
NATURE COMMUNICATIONS (2021)
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
Nicholas P. D. Liau et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)
Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase Activation
Nicholas P. D. Liau et al.
BIOCHEMISTRY (2020)
Structural basis for the action of the drug trametinib at KSR-bound MEK
Zaigham M. Khan et al.
NATURE (2020)
Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
Yasushi Kondo et al.
SCIENCE (2019)
Illustrate: Software for Biomolecular Illustration
David S. Goodsell et al.
STRUCTURE (2019)
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes
Eunyoung Park et al.
NATURE (2019)
Association of Multiple Phosphorylated Proteins with the 14-3-3 Regulatory Hubs: Problems and Perspectives
Nikolai N. Sluchanko
JOURNAL OF MOLECULAR BIOLOGY (2018)
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Zhan Yao et al.
NATURE (2017)
RAS Proteins and Their Regulators in Human Disease
Dhirendra K. Simanshu et al.
CELL (2017)
Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition
Britta Diedrich et al.
EMBO JOURNAL (2017)
Combination therapy with BRAF and MEK inhibitors for melanoma: latest evidence and place in therapy
Zeynep Eroglu et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2016)
Continuous changes in structure mapped by manifold embedding of single-particle data in cryo-EM
Joachim Frank et al.
METHODS (2016)
BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
Zhan Yao et al.
CANCER CELL (2015)
Regulation of RAF protein kinases in ERK signalling
Hugo Lavoie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
Aaron S. Mendez et al.
ELIFE (2015)
Kinase Regulation by Hydrophobic Spine Assembly in Cancer
Jiancheng Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
Neroshan Thevakumaran et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
Jacob R. Haling et al.
CANCER CELL (2014)
Kinases and Pseudokinases: Lessons from RAF
Andrey S. Shaw et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers
Jiancheng Hu et al.
CELL (2013)
Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms
Natalia Jura et al.
MOLECULAR CELL (2011)
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
Damian F. Brennan et al.
NATURE (2011)
Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
Sonja J. Heidorn et al.
CELL (2010)
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos et al.
NATURE (2010)
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou et al.
NATURE (2010)
Regulation of RAF Activity by 14-3-3 Proteins RAF KINASES ASSOCIATE FUNCTIONALLY WITH BOTH HOMO- AND HETERODIMERIC FORMS OF 14-3-3 PROTEINS
Andreas Fischer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A dimerization-dependent mechanism drives RAF catalytic activation
Thanashan Rajakulendran et al.
NATURE (2009)
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
P. J. Roberts et al.
ONCOGENE (2007)
Functional analysis of the regulatory requirements of B-Raf and the B-RafV600E oncoprotein
T. Brummer et al.
ONCOGENE (2006)
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila
M Douziech et al.
GENES & DEVELOPMENT (2006)
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: A comparison of the X-ray crystal structures of all human 14-3-3 isoforms
Alexandra K. Gardino et al.
SEMINARS IN CANCER BIOLOGY (2006)
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
PTC Wan et al.
CELL (2004)
Mutations of the BRAF gene in human cancer
H Davies et al.
NATURE (2002)
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
A Nguyen et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
KSR is a scaffold required for activation of the ERK/MAPK module
F Roy et al.
GENES & DEVELOPMENT (2002)
Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation
MC MacNicol et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
分享论文
