期刊
CURRENT OPINION IN PULMONARY MEDICINE
卷 28, 期 2, 页码 76-83出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCP.0000000000000834
关键词
bacteria; coagulopathy; small airway disease; thrombosis; virus
资金
- NIHR Manchester Biomedical Research Centre
This review examines the complex interactions between COPD and COVID-19, highlighting the evidence that COPD patients have worse outcomes from COVID-19 and the multiple mechanisms responsible.
Purpose of review Chronic obstructive pulmonary disease (COPD) and COVID-19 have many potentially negative interrelationships, which may influence the course of infection and clinical outcomes. The aim of this review is to provide clinicians with an up-to-date perspective of the complex interactions between COPD and COVID-19. Recent findings We consider mechanisms that could increase SARS-CoV-2 infection susceptibility in COPD, including increased ACE2 expression, reduced antiviral defence and dysfunctional immunity. We review evidence that COPD is associated with worse clinical outcomes from COVID-19 in analyses that have adjusted for confounding factors, and describe the mechanisms responsible. We discuss the use of inhaled corticosteroids in the context of susceptibility to COVID-19, and consider the impact of COVID-19 on the usual care of COPD patients. Summary The current review highlights the evidence that COPD patients have worse outcomes from COVID-19, and the multiple mechanisms responsible.
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