期刊
CURRENT OPINION IN PLANT BIOLOGY
卷 65, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2021.102094
关键词
ATAC-seq; Chromatin; cis-regulatory elements; Development; Single; cell; Differentiation
资金
- NSF [IOS-1856627, IOS-2026554, DBI-1905869]
- UGA Office of Research
Plant tissues and organs are composed of different cell types with variations in cell identity and function. Single-cell profiling has emerged as a powerful tool to study the relationship between cellular phenotypic variation and cis-regulatory mechanisms in plants.
Plant tissues and organs are composed of functionally discrete cell types that are all defined by the same genome sequence. Cell-type variation in part arises from differential accessibility of cis-regulatory elements that encode the blueprints for transcriptional programs underlying cell identity and function. Owing to technical limitations, the role of cis-regulatory elements in cell identity maintenance, differentiation, and functional specialization has remained relatively unexplored in plant systems. Single-cell profiling has emerged as a powerful tool to circumvent these past obstacles by enabling unbiased charting of transcriptional and cis-regulatory states at the resolution of individual cells. Here, we review state-of-the-art single-cell approaches and analytical frameworks that have paved the way for establishing the link between cellular phenotypic variation and cis-regulatory mechanisms in plants.
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