期刊
CURRENT OPINION IN PLANT BIOLOGY
卷 63, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2021.102106
关键词
Selective autophagy; Proteasome; Unfolded protein response; Organelle quality control; CDC48; Model substrates; Viral replication
资金
- Austrian Science Fund FWF [P 32355] Funding Source: Medline
Plants have evolved multitiered quality control mechanisms to maintain the integrity of organelles under stress. Our understanding of plant organelle quality control mechanisms, especially the crosstalk between different pathways, is still incomplete. Recent advances focus on targeted protein degradation pathways and propose tools for discovering missing components in organelle quality control.
Maintaining the integrity of organelles despite the cellular disturbances that arise during stress is essential for life. To ensure organelle proteostasis (protein homeostasis), plants have evolved multitiered quality control mechanisms that work together to repair or recycle the damaged organelles. Despite recent advances, our understanding of plant organelle quality control mechanisms is far from complete. Especially, the crosstalk between different quality control pathways remains elusive. Here, we highlight recent advances on organelle quality control, focusing on the targeted protein degradation pathways that maintain the homeostasis of the endoplasmic reticulum (ER), chloroplast, and mitochondria. We discuss how plant cells decide to employ different degradation pathways and propose tools that could be used to discover the missing components in organelle quality control.
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