MicroRNA: A mediator of diet-induced cardiovascular protection

Diets containing nutrients such as polyunsaturated fatty acids, polyphenols, or vitamins have been shown to have cardiovascular benefits. Micro (mi)RNAs are fundamental regulators of gene expression and function in the cardiovascular system. Diet-induced cardiovascular benefits are associated with changes in endogenous expression of miRNAs in the cardiovascular system. In addition, emerging studies have shown that miRNAs present in the food can be transported in the circulation to tissues. These exogenous miRNAs may also affect cardiovascular function contributing to the diet-induced benefits. This review discusses the emerging role of both endogenous and exogenous miRNAs as mediators of dietinduced cardiovascular protection. Understanding the mechanisms of diet-mediated actions through modulation of miRNA may provide a potential strategy for new therapies.

Automated summary

Diets rich in nutrients like polyunsaturated fatty acids, polyphenols, and vitamins have cardiovascular benefits, with miRNAs playing a crucial role in regulating gene expression in the cardiovascular system. Both endogenous and exogenous miRNAs can influence cardiovascular function, potentially providing new therapeutic strategies for diet-induced protection.