期刊
CURRENT OPINION IN PHARMACOLOGY
卷 60, 期 -, 页码 183-192出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2021.07.022
关键词
Cardiovascular disease; Diet; microRNA
资金
- Swedish Heart-Lung Foundation [20190341, 20200326, 20190266]
- Loo and Hans Ostermans Foundation [2018-01213, 2020-01209]
- Karolinska Institute [2018-01837, 2020-01473]
- Eva and Oscar Ahrens Foundation [2021-1233]
- Swedish Research Council [2020-01372]
- Novo Nordisk
- Karolinska Institute
- Swedish Research Council [2020-01372] Funding Source: Swedish Research Council
- Formas [2020-01372] Funding Source: Formas
Diets rich in nutrients like polyunsaturated fatty acids, polyphenols, and vitamins have cardiovascular benefits, with miRNAs playing a crucial role in regulating gene expression in the cardiovascular system. Both endogenous and exogenous miRNAs can influence cardiovascular function, potentially providing new therapeutic strategies for diet-induced protection.
Diets containing nutrients such as polyunsaturated fatty acids, polyphenols, or vitamins have been shown to have cardiovascular benefits. Micro (mi)RNAs are fundamental regulators of gene expression and function in the cardiovascular system. Diet-induced cardiovascular benefits are associated with changes in endogenous expression of miRNAs in the cardiovascular system. In addition, emerging studies have shown that miRNAs present in the food can be transported in the circulation to tissues. These exogenous miRNAs may also affect cardiovascular function contributing to the diet-induced benefits. This review discusses the emerging role of both endogenous and exogenous miRNAs as mediators of dietinduced cardiovascular protection. Understanding the mechanisms of diet-mediated actions through modulation of miRNA may provide a potential strategy for new therapies.
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