☆ 4.2 Review

BRAF mutations in thyroid cancer

CURRENT OPINION IN ONCOLOGY (2022)

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Review Endocrinology & Metabolism

The predictive value of coexisting BRAFV600E and TERT promoter mutations on poor outcomes and high tumour aggressiveness in papillary thyroid carcinoma: A systematic review and meta-analysis

Bojie Chen et al.

Summary: The study verified the prognostic effects of BRAFV600E and TERTp mutations in patients with papillary thyroid carcinoma. Patients with both mutations had worse prognosis, with TERTp mutation being an independent predictive factor for poor outcomes.

CLINICAL ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

BRAFV600E Overrides NOTCH Signaling in Thyroid Cancer

Florian Traversi et al.

Summary: The study indicates that the combination of BRAF and NOTCH pathways in thyroid carcinoma results in larger tumors, more aggressive cancer, and reduced survival in mice. In contrast, deletion of RBP-j kappa, a major cofactor in NOTCH signaling, did not affect the phenotype in mice. Additionally, BRAF(V600E) mutant PTC cell lines showed resistance to NOTCH pathway inhibition but responded to MEK1/2 inhibition.

THYROID (2021)

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Article Oncology

SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies

Mahesh Saqcena et al.

Summary: Mutations in SWI/SNF genes are common in thyroid cancers, leading to disease progression and decreased survival. BRAF(V600E)-mutant thyroid cancers exhibit decreased lineage transcription factor expression and impaired iodine incorporation, which can be rescued by MAPK inhibition. Loss of SWI/SNF subunits in BRAF tumors leads to a repressive chromatin state that is insensitive to the redifferentiation effects of MAPK blockade.

CANCER DISCOVERY (2021)

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Review Biochemistry & Molecular Biology

A Narrative Review of Genetic Alterations in Primary Thyroid Epithelial Cancer

Cristina Romei et al.

Summary: Thyroid carcinoma is a diverse group of cancers with distinct genetic alterations, which play a critical role in determining the biological behavior and guiding treatment strategies. Understanding these genetic events is essential for personalized and effective management of the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Public, Environmental & Occupational Health

Trend dynamics of thyroid cancer incidence among China and the US adult population from 1990 to 2017: a joinpoint and age-period-cohort analysis

Yiran Cui et al.

Summary: From 1990 to 2017, there was an increasing trend in thyroid cancer (TC) incidence rates in both China and the U.S., with higher rates for women than men. Aging was identified as a significant factor influencing TC incidence.

BMC PUBLIC HEALTH (2021)

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Article Endocrinology & Metabolism

2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer American Thyroid Association Anaplastic Thyroid Cancer Guidelines Task Force

Keith C. Bible et al.

Summary: The guidelines for the management of anaplastic thyroid cancer (ATC) aim to provide evidence-based recommendations to inform clinical decision-making, encompassing diagnosis, treatment goals, locoregional and advanced disease approaches, palliative care, surveillance, and ethical considerations.

THYROID (2021)

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Review Oncology

The SWI/SNF complex in cancer - biology, biomarkers and therapy

Priya Mittal et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Oncology

The Impact of BRAF Mutation on the Recurrence of Papillary Thyroid Carcinoma: A Meta-Analysis

Xin Li et al.

CANCERS (2020)

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Review Oncology

Clinical, Pathological, and Molecular Characteristics Correlating to the Occurrence of Radioiodine Refractory Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis

Yi Luo et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Cell Biology

BRAF: A Two-Faced Janus

Pasquale Pisapia et al.

CELLS (2020)

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Review Surgery

Prevalence of BRAF(V600E) mutation in Asian series of papillary thyroid carcinoma-a contemporary systematic review

Faiza Abdul Rashid et al.

GLAND SURGERY (2020)

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Article Endocrinology & Metabolism

Complete Surgical Resection Following Neoadjuvant Dabrafenib Plus Trametinib in BRAFV600E-Mutated Anaplastic Thyroid Carcinoma

Jennifer R. Wang et al.

THYROID (2019)

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Article Endocrinology & Metabolism

Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness

Myriem Boufraqech et al.

THYROID (2019)

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Article Oncology

A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer

Alexander J. Lin et al.

CANCER MEDICINE (2019)

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Article Oncology

Dabrafenib and Trametinib Treatment in Patients With Locally Advanced or Metastatic BRAF V600-Mutant Anaplastic Thyroid Cancer

Vivek Subbiah et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Review Endocrinology & Metabolism

Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies

Eleonora Molinaro et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

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Meeting Abstract Oncology

Results of randomized phase II trial of dabrafenib versus dabrafenib plus trametinib in BRAF-mutated papillary thyroid carcinoma.

Manisha H. Shah et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Cell Biology

Meta-Analyses of Association Between BRAF(V600E) Mutation and Clinicopathological Features of Papillary Thyroid Carcinoma

Qing Zhang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

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Article Oncology

Vemurafenib in patients with BRAFV600E-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial

Marcia S. Brose et al.

LANCET ONCOLOGY (2016)

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Article Endocrinology & Metabolism

2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer

Bryan R. Haugen et al.

THYROID (2016)

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Article Oncology

Associations between BRAFV600E and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis

Chunping Liu et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2016)

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Article Oncology

Association Between BRAF V600E Mutation and Recurrence of Papillary Thyroid Cancer

Mingzhao Xing et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Endocrinology & Metabolism

BRAF Inhibitor Dabrafenib in Patients with Metastatic BRAF-Mutant Thyroid Cancer

Gerald S. Falchook et al.

THYROID (2015)

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Article Oncology

Redifferentiation of Iodine-Refractory BRAF V600E-Mutant Metastatic Papillary Thyroid Cancer with Dabrafenib

S. Michael Rothenberg et al.

CLINICAL CANCER RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

Nishant Agrawal et al.

CELL (2014)

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Article Medicine, General & Internal

Association Between BRAF V600E Mutation and Mortality in Patients With Papillary Thyroid Cancer

Mingzhao Xing et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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