Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila

Here, we discuss findings made using Drosophila on have investigated the mechanisms underlying glia-mediated neuroprotection in AD. First, we discuss a novel mechanism of glial lipid droplet formation that occurs in response to elevated reactive oxygen species in neurons. The data suggest that disruptions to this process contribute to AD risk. We further discuss novel mechanistic insights into glia-mediated A beta 42-clearance made using the fly. Finally, we highlight work that provides evidence that the aberrant accumulation of reactive oxygen species in AD may not just be a consequence of disease but contribute to disease progression as well. Cumulatively, the discussed studies highlight recent, relevant discoveries in AD made using Drosophila.

Automated summary

Here, we discuss recent findings in AD research using Drosophila, focusing on mechanisms underlying glia-mediated neuroprotection, including glial lipid droplet formation, A beta 42-clearance, and the role of aberrant accumulation of reactive oxygen species.