Inflammasome activation by Salmonella

Host recognition of bacteria such as Salmonella enterica serovar Typhimurium requires multiple host detection systems to generate complex inflammatory responses which can be cell type specific and has the potential for bacterial subversion of the host. Host detection of Salmonella requires Pattern Recognition Receptors (PRRs) sensing Pathogen Associated Molecular Patterns (PAMPs). These bacteria possess a diverse array of PAMPs including lipopolysaccharide, flagellin, proteins, lipoproteins, DNA, RNA and metabolites which can potentially activate multiple PRRs concurrently in different cell types. Salmonella is sensed by the inflammasome forming cytosolic nucleotide oligomerisation domain leucine rich repeat-like receptor (NLR) PRRs NLRC4 and NLRP3 as well as by the non canonical inflammasome formed by caspase 11 in mice, caspase 4 and 5 in humans. This review will discuss the different inflammasomes and how their activity regulates the host response to Salmonella infection.

Automated summary

Host recognition of bacteria like Salmonella enterica serovar Typhimurium requires multiple host detection systems to generate complex inflammatory responses which can be cell type specific and has the potential for bacterial subversion of the host. The bacteria possess a diverse array of PAMPs that can potentially activate multiple PRRs concurrently in different cell types. Different inflammasomes play important regulatory roles in the host response to Salmonella infection.