期刊
CURRENT OPINION IN IMMUNOLOGY
卷 72, 期 -, 页码 277-285出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2021.06.017
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资金
- ITMO Cancer of Aviesan
- INCa [2021-2030]
- French Primary Immunodeficiency Reference Center (CEREDIH)
- French Cancer Institute (INCa) [2013-1-PL BIO-11-1]
- National Center for Advancing Translational Sciences (NCATS),National Institutes of Health (NIH) [5 R21 AI107508-02, 1R01AI43810-01]
- National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program [UL1TR001866]
- French National Research Agency (ANR) under the `Investments for the future' program [ANR-10-IAHU-01]
- Integrative Biology of Emerging Infectious Diseases Laboratoire d'Excellence (ANR10-LABX-62-IBEID) [ANR-18-CE15-0020-02]
- SEAe-HostFactors grant [ANR-18-CE15-0020-02]
- ANR grant
- NKD grant [ANR-15-CE15-0013-01]
- Rockefeller University, Institut National de la Sante' et de la Recherche Me' dicale (INSERM)
- Howard Hughes Medical Institute, Paris Descartes University
- St. Giles Foundation
- Agence Nationale de la Recherche (ANR) [ANR-15-CE15-0013] Funding Source: Agence Nationale de la Recherche (ANR)
Oncoviruses are viruses that can cause tumors, with seven viruses currently recognized as oncogenic in humans. Infections with these oncoviruses can result in a wide range of clinical phenotypes from asymptomatic infection to invasive cancers. Studies of patients with inborn errors of immunity have helped deepen our understanding of the mechanisms controlling infections with certain oncoviruses.
Oncoviruses are viruses that can cause tumors. Seven viruses are currently recognized as oncogenic in humans: Epstein Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV, also known as HHV8), human papillomaviruses (HPVs), hepatitis B virus (HBV), hepatitis C virus (HCV), human T-lymphotropic virus-1 (HTLV-1), and Merkel cell polyomavirus (MCPyV). The clinical phenotypes resulting from infection with these oncoviruses range from asymptomatic infection to invasive cancers. Patients with inborn errors of immunity (IEI) are prone to the development of infectious diseases caused by a narrow or broad spectrum of pathogens, including oncoviruses in some cases. Studies of patients with IEI have deepened our understanding of the non-redundant mechanisms underlying the control of EBV, HHV8 and HPV infections. The human genetic factors conferring predisposition to oncogenic HBV, HCV, HTLV-1 and MCPyV manifestations remain elusive. We briefly review here what is currently known about the IEI conferring predisposition to severe infection with oncoviruses.
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