Autoimmunity, IgE and FceRI-bearing cells

Antibody-mediated autoimmune diseases (AAID) involve several isotypes of autoreactive antibodies. In a growing number of AAID, autoreactive IgE are present with a significant prevalence and are often associated with the presence of IgG anti-IgE and/or anti-FceRIa (high affinity IgE receptor a chain). FceRI-bearing cells, such as basophils or mast cells, are key players in some of these AAID. Recent advances in the pathophysiology of these diseases led to the passed or current development of anti-IgE strategies that showed very potent effects in some of them. The present review centralizes the information on the relevance of autoreactive IgE and FceRIbearing cells in the pathophysiology of different AAID and the ones where the anti-IgE therapeutic strategy shows or may show some benefits for the patients.

Automated summary

Antibody-mediated autoimmune diseases involve various autoreactive antibodies, with IgE playing a significant role in some cases. Cells bearing FceRI, such as basophils or mast cells, are crucial in these diseases. Advancements in pathophysiology have led to the development of anti-IgE strategies that show promising effects in certain conditions.