The role of tissue maturity and mechanical state in controlling cell extrusion

Epithelia remove dying or excess cells by extrusion, a process that seamlessly squeezes cells out of the layer without disrupting their barrier function. New studies shed light into the intricate relationship between extrusion, tissue mechanics, and development. They emphasize the importance of whole tissuemechanics, rather than single cell-mechanics in controlling extrusion. Tissue compaction, stiffness, and cell-cell adhesion can impact the efficiency of cell extrusion and mechanisms that drive it, to adapt to different conditions during development or disease.

Automated summary

Epithelia remove dying or excess cells through a process called extrusion, which is influenced by tissue mechanics and development. New studies highlight the significance of tissue mechanics as a whole, rather than individual cell mechanics, in controlling extrusion. Factors such as tissue compaction, stiffness, and cell-cell adhesion can affect the efficiency of cell extrusion and the mechanisms involved in adapting to different developmental or disease conditions.