4.1 Review

Faecal microbiota replacement to eradicate antimicrobial resistant bacteria in the intestinal tract - a systematic review

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Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms

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Summary: Although FMT produces variable intestinal decolonization results for MDROs, this study demonstrated significant reductions in antibiotic duration, bacteremia, and length of stay in patients colonized/infected with MDRO receiving FMT, despite modest decolonization rates.

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Summary: The study provides a biological explanation for the effectiveness of FMT against CPE carriage, suggesting that the decolonization of CPE is likely mediated by changes in the composition and function of the microbiome.

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Eosinophilic gastroenteritis and graft-versus-host disease induced by transmission of Norovirus with fecal microbiota transplant

Jaroslaw Bilinski et al.

Summary: Fecal microbiota transplantation (FMT) was effective in decolonizing antibiotic-resistant bacteria before allogeneic hematopoietic cells transplantation (alloHCT). Complications during alloHCT, including norovirus infection, were resolved after a second FMT from a different donor.

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Alteration of Gut Microbiota in Carbapenem-Resistant Enterobacteriaceae Carriers during Fecal Microbiota Transplantation According to Decolonization Periods

Jin-Jae Lee et al.

Summary: The study evaluated changes in gut microbiota of CRE carriers during FMT and found it to be a potential option for CRE decolonization. The analysis of gut microbiota could help predict decolonization timing after FMT and determine the necessity of repeated FMT.

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Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

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Fecal Microbiota Transplantation as an Effective Treatment for Carbapenem-Resistant Klebsiella pneumoniae Infection in a Renal Transplant Patient

Junpeng Wang et al.

Summary: This study demonstrated the therapeutic effect of FMT on infections caused by CRKP for a renal transplant patient. By analyzing microbial characteristics and diversity, the study showed that the microbial composition of the patient post FMT resembled the donor composition, indicating potential therapeutic effects.

INFECTION AND DRUG RESISTANCE (2021)

Review Medicine, General & Internal

Is there a role of faecal microbiota transplantation in reducing antibiotic resistance burden in gut? A systematic review and Meta-analysis

Priyanga Dharmaratne et al.

Summary: The study aimed to investigate the therapeutic efficacy of fecal microbiota transplantation (FMT) for the decolonization of antimicrobial-resistant (AMR) bacteria from the gut, showing that FMT has a certain effectiveness in AMR remission. However, research on this topic is still limited, and more rigorous randomized controlled trials are needed to further validate the findings.

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Tandem fecal microbiota transplantation cycles in an allogeneic hematopoietic stem cell transplant recipient targeting carbapenem-resistant Enterobacteriaceae colonization: a case report and literature review

Fengqin Su et al.

Summary: Limited antibiotic options contribute to high non-relapse mortality in allo-HSCT patients with carbapenem-resistant Enterobacteriaceae (CRE) infections. Intestinal CRE colonization is a risk factor for subsequent CRE infection. Fecal microbiota transplantation (FMT) has shown success in decolonizing multidrug-resistant bacteria (MDRB) and may be a potential option for CRE decolonization, as seen in this case report.

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Intestinal Dysbiosis in Carriers of Carbapenem-Resistant Enterobacteriaceae

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Multidrug-Resistant Bacterial Infections in US Hospitalized Patients, 2012-2017

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ESCMID-EUCIC clinical guidelines on decolonization of multidrug-resistant Gram-negative bacteria carriers

E. Tacconelli et al.

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Rafael Araos et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2017)

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Multidrug-resistant gram-negative bacteria in a long-term care facility: Prevalence and risk factors

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