Recent advances in surface-active ionic liquid-assisted self-assembly systems for drug delivery

Article Chemistry, Physical

Insights into the interaction of Bovine Serum Albumin with Surface-Active Ionic Liquids in aqueous solution

Marcia M. S. Alves et al.

Summary: The study investigates the interaction of fluorinated ionic liquids with bovine serum albumin (BSA), demonstrating the potential application value of fluorinated ionic liquids in stabilizing and structurally affecting BSA.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Chemistry, Physical

Investigations on the micellization behavior and thermodynamic characteristics of synthesized surface active ionic liquids [C14mim] [Br] and [C15mim] [Br] in the presence of oral antidiabetic drug metformin hydrochloride

Harsh Kumar et al.

Summary: This study focuses on the micellization behavior of two surface-active ionic liquids in the presence of an antidiabetic drug, investigating thermodynamic parameters and structural changes. The increase in CMC value with temperature indicates a delay in the micellization process. Structural alterations in the system were determined using FT-IR Spectroscopy.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Chemistry, Physical

Ionic liquid-based catanionic vesicles: A de novo system to judiciously improve the solubility, stability and antimicrobial activity of curcumin

Monika Jain et al.

Summary: Encapsulating curcumin within vesicles enhances its solubility and stability, protecting it from enzymatic degradation in biological fluids and improving its medicinal effects. Catanionic vesicles formed through synergistic interactions have a higher hydrophobic character, effectively encapsulating curcumin and exhibiting antibacterial properties.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Engineering, Chemical

Permeability of Vesicles for Imidazolium-Based Ionic Liquids in Aqueous Solution: A Molecular Dynamic Simulation Study

Kun Jiang et al.

Summary: The self-assembly behavior of ionic liquids in aqueous solution was studied through molecular dynamics simulations, revealing the dominant role of interactions between tail groups in stabilizing vesicles and the influence of membrane thickness and alkyl chain arrangement on vesicle permeability. The interdigitated structure of tail groups reduced water exchange rate, while the orientation of the imidazolium ring promoted water molecules approaching hydrophobic regions. These findings suggest the potential for obtaining vesicles with excellent permeability properties by screening the hydrophilic and hydrophobic properties of ILs for applications in separation and drug delivery processes.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2021)

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Article Chemistry, Physical

Synergistic aggregation of the ibuprofenate anion and a a double-strand imidazolium cation into vesicles for drug delivery: a simulation study

Tahereh Ghaed-Sharaf et al.

Summary: A novel ionic liquid-based lipid has been studied for drug delivery, showing the formation of stable vesicles as drug carriers in aqueous media through the formation of ion pairs. The addition of monovalent salts enhances the stability of the vesicles, while divalent salts lead to coagulation through complexation with head groups. The solid-like character of the vesicle wall is evidenced by the radial distribution function, indicating synergistic aggregation.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Nanoscience & Nanotechnology

Biocompatible Ionic Liquid-Mediated Micelles for Enhanced Transdermal Delivery of Paclitaxel

Md Korban Ali et al.

Summary: The new MF showed enhanced transdermal absorption of PTX, lower toxicity profile compared to conventional carriers, demonstrating potential as a biocompatible nanocarrier for effective delivery of poorly soluble chemotherapeutics.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Physical

Comparison of the interaction between propranolol hydrochloride (PPL) with anionic surfactant and cationic surface active ionic liquid in micellar phase

Ahmad Bagheri

Summary: In this study, the interaction between an amphiphilic drug and ionic surfactants in binary mixtures was investigated in the micellar phase using conductometric technique. The results showed attractive interactions between components in both systems, with the NLS/PPL system exhibiting stronger micelle formation capability and synergistic effects. Conductometry measurements indicated higher extent of counterion binding in mixed micelles for the SAIL/PPL system compared to the NLS/PPL system.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Article Pharmacology & Pharmacy

Biocompatible ionic liquids assisted transdermal co-delivery of antigenic protein and adjuvant for cancer immunotherapy

Md Raihan Chowdhury et al.

Summary: A study developed an ionic liquid-assisted delivery system for successful transdermal delivery of an antigenic protein, inducing a specific immune response. Both the ionic liquids and ILDS were biocompatible and showed potential for therapeutic purposes.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Acoustics

Synergic effects of ultrasound and ionic liquids on fluconazole emulsion

Bruno L. Hennemann et al.

Summary: This study evaluated the influence of ultrasound on the properties of fluconazole emulsions. The results showed that emulsions prepared with ultrasound had smaller droplet sizes and lower polydispersity. The concentration of IL and alkyl chain length also affected the emulsion stability and encapsulation efficiency.

ULTRASONICS SONOCHEMISTRY (2021)

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Review Polymer Science

Ionic Liquid-Based Surfactants: Recent Advances in Their Syntheses, Solution Properties, and Applications

Omar A. El Seoud et al.

Summary: The increasing interest in ionic liquids (ILs) is driven by their favorable properties and diverse applications, especially in the form of ionic liquid-based surfactants (ILBSs). ILBSs show potential in various fields such as catalysis, polymers, and drug delivery, and their use as templates for mesoporous nanoparticles allows for better control over particle properties. ILBSs also form stable water/oil and oil/water microemulsions, which can be utilized in polymerization reactions and other applications.

POLYMERS (2021)

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Review Chemistry, Multidisciplinary

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

Harsh Kumar et al.

Summary: Researchers have explored the self-assembly and aggregation behavior of different surface-active molecules, and found that the addition of ILs and SAILs significantly influence the surface-activity and aggregation behavior of conventional surfactants.

FRONTIERS IN CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Temperature- and Composition-Induced Multiarchitectural Transitions in the Catanionic System of a Conventional Surfactant and a Surface-Active Ionic Liquid

Mohd Sajid Lone et al.

Summary: The mixture of cetyltrimethylammonium bromide (CTAB) and 1-butyl-3-methylimidazoliumdodecyl sulfate (bmimDS) has been found to undergo phase transitions from vesicles to micelles as a function of temperature, with some mole fractions of CTAB showing dual transitions. Solutions with certain mole fractions exhibit a single transition from vesicles to cylindrical micelles, while others show dual structural transitions at different temperatures. This unique microstructural transition in a combination of cationic and anionic surfactants without additives has not been reported previously.

ACS OMEGA (2021)

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Article Chemistry, Physical

Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity

Patricia Regina Ebani et al.

Summary: New nanocarriers based on carboxymethyl chitosan (CMC) and ionic liquid imidazolium-based (IL) have been developed for third-generation photosensitizers in photodynamic therapy (PDT). These nanoparticles exhibit excellent physicochemical properties, drug release profiles, and potential for application in PDT.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Polymer Science

Mixed Micellization and Spectroscopic Studies of Anti-Allergic Drug and Non-Ionic Surfactant in the Presence of Ionic Liquid

Naved Azum et al.

Summary: This study investigated the interaction between a drug and a surfactant mixture in various conditions, revealing synergistic behavior at the surface and in bulk. Energetic parameters indicated the thermodynamic advantage of micelle formation and surfactant adsorption. Theoretical models and experimental techniques were used to estimate various physicochemical parameters.

POLYMERS (2021)

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Article Chemistry, Multidisciplinary

pH Changes in the Micelle-Water Interface of Surface-Active Ionic Liquids Dictate the Stability of Encapsulated Curcumin: An Insight Through a Unique Interfacial Reaction between Arenediazonium Ions and t-Butyl Hydroquinone

Saima Afzal et al.

Summary: The study utilized the chemical kinetic method to investigate the changes in the chemical reactivity of anionic surface-active ionic liquids (SAILs) as a function of concentration and composition in mixed states. The structural transitions of the SAIL aggregates and reduction kinetics of 16-ArN2+ at the interface provided insight into the changes in the interfacial H+ ions, correlating well with the stability of curcumin within the self-assemblies.

ACS OMEGA (2021)

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Article Nanoscience & Nanotechnology

Lipid-Based Ionic-Liquid-Mediated Nanodispersions as Biocompatible Carriers for the Enhanced Transdermal Delivery of a Peptide Drug

Shihab Uddin et al.

Summary: By encapsulating peptide-LBIL complexes in an oil phase, the physiochemical stability, drug-loading capacity, and drug encapsulation efficiency were significantly increased, leading to enhanced transdermal delivery. Among all the LBIL-based formulations, [EDMPC][Linoleate]/O-ND was considered the most preferable for a TDDS based on pharmacokinetic parameters.

ACS APPLIED BIO MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Design Principles of Lipid-like Ionic Liquids for Gene Delivery

David J. Siegel et al.

Summary: A novel lipid-like ionic liquid was developed as a potential carrier for gene delivery, with a combination of design, synthesis, and computational modeling used to rationalize self-assembly and biological properties. This work may offer insights into the design principles for synthetic vectors based on self-assembly behavior.

ACS APPLIED BIO MATERIALS (2021)

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Article Multidisciplinary Sciences

Development of ionic liquid microemulsion for transdermal delivery of a chemotherapeutic agent

Harish Sharma et al.

Summary: This study focused on synthesizing an innovative 5-FU microemulsion as a topical delivery system for skin cancer treatment, increasing drug release and designing a topical gel to prolong drug release. The results of this study were satisfactory for the treatment of skin cancer.

SN APPLIED SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Biocompatible Ionic Liquid Surfactant-Based Microemulsion as a Potential Carrier for Sparingly Soluble Drugs

Md Korban Ali et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2020)

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Article Biochemistry & Molecular Biology

Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine

Ana Teresa Silva et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Pharmacology & Pharmacy

In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

Eleni Kontogiannidou et al.

PHARMACEUTICS (2020)

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Article Medicine, Research & Experimental

Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect

Yoshiro Tahara et al.

MOLECULAR PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Concentration- and Temperature-Responsive Reversible Transition in Amide-Functionalized Surface-Active Ionic Liquids: Micelles to Vesicles to Organogel

Muzammil Kuddushi et al.

ACS OMEGA (2020)

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Article Chemistry, Multidisciplinary

The Role of Imidazolium-Based Surface-Active Ionic Liquid to Restrain the Excited-State Intramolecular H-Atom Transfer Dynamics of Medicinal Pigment Curcumin: A Theoretical and Experimental Approach

Swati Rani et al.

ACS OMEGA (2020)

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Article Chemistry, Physical

Functionalized surfactant based catanionic vesicles as the soft template for the synthesis of hollow silica nanospheres as new age drug carrier

Sargam M. Rajput et al.

SURFACES AND INTERFACES (2020)

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Article Chemistry, Physical

Spontaneous formation of unilamellar vesicles based on the surfactant 1-methylimidazolium bis-(2-ethylhexyl) phosphate, evaluated as a function of pH and in saline solution

Heber E. Andrada et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2020)

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Article Chemistry, Physical

Formation and potential application of micelles composed of biocompatible N-lauroyl-amino acid ionic liquids surfactant

Rahman Md Moshikur et al.

JOURNAL OF MOLECULAR LIQUIDS (2020)

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Review Chemistry, Multidisciplinary

Biocompatible ionic liquids and their applications in pharmaceutics

Rahman Md Moshikur et al.

GREEN CHEMISTRY (2020)

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Article Pharmacology & Pharmacy

pH-Responsive Nanostructures Based on Surface Active Fatty Acid-Protic Ionic Liquids for Imiquimod Delivery in Skin Cancer Topical Therapy

Silvia Tampucci et al.

PHARMACEUTICS (2020)

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Article Materials Science, Biomaterials

Magnetic proline-based ionic liquid surfactant as a nano-carrier for hydrophobic drug delivery

Akshay Kulshrestha et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Physical

Synthesis and characterization of choline-fatty-acid-based ionic liquids: A new biocompatible surfactant

Md Korban Ali et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Pharmacology & Pharmacy

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Shuo Chen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Article Chemistry, Physical

Effect of rifampicin on the interfacial properties of imidazolium ionic liquids and its solubility therein

Ab Raouf Bhat et al.

JOURNAL OF MOLECULAR LIQUIDS (2019)

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Article Chemistry, Multidisciplinary

Acute Aquatic Toxicity and Biodegradability of Fluorinated Ionic Liquids

Nicole S. M. Vieira et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2019)

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Article Chemistry, Multidisciplinary

Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity

Md. Raihan Chowdhury et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Physical

Mixed micellization of an amphiphilic drug amitriptyline hydrochloride and surface active ionic liquids: Interfacial and micellization studies

Amalendu Pal et al.

CHEMICAL PHYSICS LETTERS (2018)

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Article Chemistry, Physical

Investigations of drug binding ability of a trisubstituted surface active ionic liquid 1-dodecy1-2,3-dimethylimidazolium chloride [C(12)bmim][Cl]

Amalendu Pal et al.

JOURNAL OF MOLECULAR LIQUIDS (2018)

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Article Chemistry, Physical

Interactions Between Surface Active Ionic Liquid and Procaine Hydrochloride Drug in Aqueous Solution

Amalendu Pal et al.

JOURNAL OF SOLUTION CHEMISTRY (2018)

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Article Engineering, Chemical

Valorization of olive tree leaves: Extraction of oleanolic acid using aqueous solutions of surface-active ionic liquids

Ana Filipa M. Claudio et al.

SEPARATION AND PURIFICATION TECHNOLOGY (2018)

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Article Pharmacology & Pharmacy

Fluorinated ionic liquids for protein drug delivery systems: Investigating their impact on the structure and function of lysozyme

Marcia Alves et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Physical

Nicotine-based surface active ionic liquids: Synthesis, self-assembly and cytotoxicity studies

Gurbir Singh et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2017)

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Article Chemistry, Multidisciplinary

Cholesterol Based Surface Active Ionic Liquid That Can Form Microemulsions and Spontaneous Vesicles

Arghajit Pyne et al.

LANGMUIR (2017)

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Article Medicine, Research & Experimental

Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies

Yasemin Sahbaz et al.

MOLECULAR PHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Aqueous Solutions of Surface-Active Ionic Liquids: Remarkable Alternative Solvents To Improve the Solubility of Triterpenic Acids and Their Extraction from Biomass

Emanuelle L. P. de Faria et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2017)

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Article Chemistry, Physical

The interaction of a model active pharmaceutical with cationic surfactant and the subsequent design of drug based ionic liquid surfactants

Sara Qamar et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2016)

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Article Medicine, Research & Experimental

Transformation of Poorly Water-Soluble Drugs into Lipophilic Ionic Liquids Enhances Oral Drug Exposure from Lipid Based Formulations

Yasemin Sahbaz et al.

MOLECULAR PHARMACEUTICS (2015)

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Article Chemistry, Multidisciplinary

Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Hywel D. Williams et al.

CHEMICAL COMMUNICATIONS (2014)

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Recent advances in surface-active ionic liquid-assisted self-assembly systems for drug delivery

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