期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 73, 期 -, 页码 308-313出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.09.007
关键词
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资金
- Sentinel North program at Universite Laval
- Canada First Research Excellence Fund
- Fonds de recherche du Quebec - Nature et Technologie (FRQNT)
- Sentinel North
- T1 Canada Research Chair in Bacteriophages
The zebrafish model is gaining attention for investigating microbiota-host interactions due to its low cost, ability to assess large cohorts, and availability of optical methodologies. Recent findings have revealed the modulation of zebrafish gut microbiota by exogenous microbes, nutrition, and environmental factors. This model also shows potential for assessing the impact of gut microbiota on brain development.
The importance of the gut microbiota in host health is now well established, but the underlying mechanisms remain poorly understood. Among the animal models used to investigate microbiota-host interactions, the zebrafish (Danio renio) is gaining attention. Several factors contribute to the recent interest in this model, including its low cost, the ability to assess large cohorts, the possibility to obtain germ-free larvae from non-axenic parents, and the availability of optical methodologies to probe the transparent larvae and adults from various genetic lines. We review recent findings on the zebrafish gut microbiota and its modulation by exogenous microbes, nutrition, and environmental factors. We also highlight the potential of this model for assessing the impact of the gut microbiota on brain development. (C) 2021 Elsevier Ltd. All rights reserved.
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