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Creating an atlas to visualize the biodiversity of the mammalian gut microbiota*

期刊

CURRENT OPINION IN BIOTECHNOLOGY
卷 73, 期 -, 页码 28-33

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ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.06.028

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资金

  1. EU Joint Programming Initiative A Healthy Diet for a Healthy Life (JPI HDHL)
  2. Science Foundation Ireland [SFI] [15/JP-HDHL/3280]
  3. SFI through the Irish Government's National Development Plan [SFI/12/RC/2273-P1, SFI/12/RC/2273-P2]

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Given the importance of the intestinal microbial community in host health, there have been increased efforts to determine its composition and functions. Next-Generation Sequencing techniques and bioinformatic tools have provided an exciting opportunity to expand our knowledge on intestinal microbial communities. Factors such as diet, host phylogeny, host physiology, and human activities play a major role in selecting a specific gut microbial consortium in mammals.
Given the fundamental role played by the intestinal microbial community in influencing host health, it is not surprising that recent decades have been marked by increased efforts to determine the taxonomic composition of the human gut microbiota and its associated functions. Despite their generally accepted importance, these large-scale human-centered studies prevent an exhaustive overview of those mechanisms and factors that contribute to the mammalian gut microbiota assembly. However, Next-Generation Sequencing techniques and associated bioinformatic tools provide an exciting opportunity to rapidly expand our knowledge on the intestinal microbial communities associated with members of the Mammalia class. These non-human-focused studies established that dietary, host phylogeny, host physiology and anthropogenic influences represent the main factors driving the selection of a specific gut microbial consortium in mammals. The current review is aimed at providing a comprehensive overview on the impact that the above-mentioned factors exert on the assembly of the mammalian gut microbiota.

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