☆ 4.6 Review

PCSK9 as a New Player in Cancer: New Opportunity or Red Herring?

CURRENT MEDICINAL CHEMISTRY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Protein convertase subtilisin/Kexin type 9 inhibits hepatocellular carcinoma growth by interacting with GSTP1 and suppressing the JNK signaling pathway

Mingyan He et al.

Summary: This study found that the low expression of PCSK9 protein is associated with tumor development and clinical outcomes in hepatocellular carcinoma. PCSK9 inhibits the proliferation and metastasis of HCC cells through interaction with GSTP1 and suppression of the JNK signaling pathway.

CANCER BIOLOGY & MEDICINE (2022)

添加到收藏夹

Article Medicine, General & Internal

PCSK9 is associated with mortality in patients with septic shock: data from the ALBIOS study

A. Vecchie et al.

Summary: In this study, it was found that patients with septic shock who had lower plasma PCSK9 levels tended to experience higher mortality rates. Further studies are needed to better assess the pathophysiological role of PCSK9 in sepsis.

JOURNAL OF INTERNAL MEDICINE (2021)

添加到收藏夹

Review Cell Biology

Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall

Yanan Guo et al.

Summary: PCSK9 plays a crucial role in vascular diseases by regulating LDL cholesterol levels, and monoclonal antibodies targeting PCSK9 have shown to reduce LDL levels and cardiovascular events, leading to potential advancements in lipid-lowering therapy and disease prevention.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

添加到收藏夹

Article Oncology

Proprotein Convertase Subtilisin/Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apoptosis by Facilitating MAPK Signaling Pathway Through HSP70 Up-Regulation

Beili Xu et al.

Summary: This study demonstrates that high expression of PCSK9 in gastric cancer tissues is associated with tumor progression and poor prognosis. PCSK9 promotes gastric cancer metastasis and suppresses apoptosis through facilitating the MAPK signaling pathway via upregulation of HSP70. PCSK9 may serve as a potential therapeutic target in gastric cancer.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Peripheral Vascular Disease

Lipid Lowering Drugs: Present Status and Future Developments

Massimiliano Ruscica et al.

Summary: In addition to statins, other non-statin lipid lowering approaches are needed to reduce cardiovascular burden in patients at highest risk. Recent findings show promising benefits with drugs like bempedoic acid, inclisiran, and icosapent ethyl for managing hypercholesterolemia and hypertriglyceridemia. RNA-based therapies also offer new options for reducing lipoprotein(a) and triglyceride levels.

CURRENT ATHEROSCLEROSIS REPORTS (2021)

添加到收藏夹

Article Cell Biology

Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling

Juanjuan Yuan et al.

Summary: The study reveals the crucial role of LDLR in regulating the antitumor activity of CD8(+) T cells, including promoting T cell priming and clonal expansion, as well as regulating TCR signaling through interaction with the TCR complex. Moreover, the tumor microenvironment suppresses LDLR and TCR signaling in CD8(+) T cells via PCSK9, inhibiting the effector function of CTLs.

PROTEIN & CELL (2021)

添加到收藏夹

Review Pathology

Proprotein Convertase Subtilisin/Kexin Type 9 A View beyond the Canonical Cholesterol-Lowering Impact

Chiara Macchi et al.

Summary: PCSK9, mainly synthesized and released by the liver, is a key regulator of low-density lipoprotein cholesterol, with potential non-cholesterol-related effects in inflammatory burden, triglyceride-rich lipoprotein metabolism, platelet activation, and possibly in diseases such as diabetes, obesity, and cancer. Further research is needed to understand the diverse roles of PCSK9 in various physiological and pathological processes.

AMERICAN JOURNAL OF PATHOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B

Nick S. Nurmohamed et al.

Summary: Novel therapies targeting LDL-C, including inclisiran, bempedoic acid, ANGPTL3 inhibitors, and CETP inhibitors, provide important tools for the prevention of cardiovascular disease.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Endocrine toxicities of immune checkpoint inhibitors

Jordan J. Wright et al.

Summary: Immune checkpoint inhibitors (ICIs) have become a cornerstone of cancer therapeutics, but can also cause toxicities in various organs known as immune-related adverse events. ICIs can lead to endocrinopathies involving the thyroid, pituitary, adrenal glands, and pancreas, which are common and sometimes fatal.

NATURE REVIEWS ENDOCRINOLOGY (2021)

添加到收藏夹

Article Oncology

PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma

Shi-Zhe Zhang et al.

Summary: The study revealed that high expression of PCSK9 in hepatocellular carcinoma (HCC) is associated with microvascular invasion and large tumor size, leading to poor overall survival and disease-free survival in patients. Experimental findings demonstrated that PCSK9 promotes HCC growth by inhibiting cell apoptosis, with FASN-mediated anti-apoptosis playing a significant role in this process.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Proprotein convertase subtilisin/kexin type 9 (PCSK9): A potential multifaceted player in cancer

Anindita Bhattacharya et al.

Summary: PCSK9 has emerged as a novel pharmacological target for hypercholesterolemia and associated cardiovascular diseases, and its aberrant expression in a broad spectrum of cancers suggests its potential as a valuable biomarker and therapeutic target in personalized cancer medicine.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

添加到收藏夹

Article Medicine, Research & Experimental

PCSK9 and cancer: Rethinking the link

Khadijeh Mahboobnia et al.

Summary: PCSK9 plays an important role in the development and progression of various cancers, highlighting its potential significance in cancer treatment. Inhibiting PCSK9 may help suppress the proliferation and invasion of tumor cells. However, the current lack of data on the role of PCSK9 in cancer and the impact of PCSK9 inhibition in cancer therapy limits our understanding of its effectiveness and safety.

BIOMEDICINE & PHARMACOTHERAPY (2021)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

PCSK9 vaccine: so near, yet so far!

Amirhossein Sahebkar et al.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Oncology

Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells

Jung Min Suh et al.

Summary: The study reveals that Ahnak regulates tumor metastasis through controlling the expression of PCSK9. Ahnak(-/-) mice show higher resistance to B16F10 melanoma cell pulmonary metastasis, while PCSK9 plays a crucial role in the metastasis of melanoma cells.

NEOPLASIA (2021)

添加到收藏夹

Article Oncology

Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors

Dafne Jacome Sanz et al.

Summary: Ovarian cancer has a poor prognosis due to late diagnosis and lack of reliable biomarkers. Lipid metabolism plays a crucial role in ovarian cancer progression. Targeting enzymes involved in lipid metabolism regulation can impair cancer cell growth. Different mTOR inhibitors show varying levels of cytotoxic activity in ovarian cancer cell lines and patient-derived cancer cell cultures, suggesting the potential for targeted therapies based on subtype-specific drug vulnerabilities.

CANCERS (2021)

添加到收藏夹

Article Oncology

Association of Serum Anti-PCSK9 Antibody Levels with Favorable Postoperative Prognosis in Esophageal Cancer

Masaaki Ito et al.

Summary: Patients with solid cancer had higher levels of anti-PCSK9 antibodies in serum compared to healthy donors. High levels of anti-PCSK9 antibodies indicated a better prognosis for overall survival after surgery in patients with esophageal cancer, and the study confirmed the association between these antibody levels and PD-L1 levels.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

PCSK9 and inflammation: role of shear stress, pro-inflammatory cytokines, and LOX-1

Zufeng Ding et al.

CARDIOVASCULAR RESEARCH (2020)

添加到收藏夹

Letter Medicine, General & Internal

PCSK9 decreases during experimental endotoxemia

C. Schoergenhofer et al.

JOURNAL OF INTERNAL MEDICINE (2020)

添加到收藏夹

Letter Oncology

PCSK9 is a promising prognostic marker in patients with advanced NSCLC

Aldo Bonaventura et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Sex-specific predictors of PCSK9 levels in a European population: The IMPROVE study

Nicola Ferri et al.

ATHEROSCLEROSIS (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor

Khaldoun S. Abdelwahed et al.

PHARMACOLOGICAL RESEARCH (2020)

添加到收藏夹

Article Biology

Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank

Paul Carter et al.

ELIFE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer

Xinjian Liu et al.

NATURE (2020)

添加到收藏夹

Article Medicine, General & Internal

Effects of immunisation against PCSK9 in mice bearing melanoma

Amir Abbas Momtazi-Borojeni et al.

ARCHIVES OF MEDICAL SCIENCE (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Vaccines Targeting PSCK9 for the Treatment of Hyperlipidemia

Stefan Toth et al.

CARDIOLOGY AND THERAPY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Safety and Tolerability of PCSK9 Inhibitors: Current Insights

Constantine E. Kosmas et al.

CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Long-term generation of antiPCSK9 antibody using a nanoliposome-based vaccine delivery system

Amir Abbas Momtazi-Borojeni et al.

ATHEROSCLEROSIS (2019)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

PCSK9 inhibition and inflammation: A narrative review

Massimiliano Ruscica et al.

ATHEROSCLEROSIS (2019)

添加到收藏夹

Article Oncology

Serum PCSK9 levels at the second nivolumab cycle predict overall survival in elderly patients with NSCLC: a pilot study

Aldo Bonaventura et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Proprotein convertase subtilisin/kexin type 9 and lipid metabolism

Stefano Spolitu et al.

CURRENT OPINION IN LIPIDOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Reduced plasma PCSK9 response in patients with bacteraemia is associated with mortality

J. Rannikko et al.

JOURNAL OF INTERNAL MEDICINE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Emerging roles of low-density lipoprotein in the development and treatment of breast cancer

Xuefeng Guan et al.

LIPIDS IN HEALTH AND DISEASE (2019)

添加到收藏夹

Review Medicine, General & Internal

Immune Checkpoint Inhibitor Toxicities

Julian A. Marin-Acevedo et al.

MAYO CLINIC PROCEEDINGS (2019)

添加到收藏夹

Review Medicine, General & Internal

HDL and LDL: Potential New Players in Breast Cancer Development

Lidia Cedo et al.

JOURNAL OF CLINICAL MEDICINE (2019)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Cardiovascular Toxicities of Immune Checkpoint Inhibitors JACC Review Topic of the Week

Somedeb Ball et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

添加到收藏夹

Review Hematology

PCSK9 in Haemostasis and Thrombosis: Possible Pleiotropic Effects of PCSK9 Inhibitors in Cardiovascular Prevention

Francesco Paciullo et al.

THROMBOSIS AND HAEMOSTASIS (2019)

添加到收藏夹

Article Medicine, General & Internal

Effects of immunization against PCSK9 in an experimental model of breast cancer

Amir Abbas Momtazi-Borojeni et al.

ARCHIVES OF MEDICAL SCIENCE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction

Hua Sun et al.

JOURNAL OF LIPID RESEARCH (2018)

添加到收藏夹

Article Oncology

Ovarian Cancer Statistics, 2018

Lindsey A. Torre et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Establishment and Characterization of the Novel High-Grade Serous Ovarian Cancer Cell Line OVPA8

Patrycja Tudrej et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Multidisciplinary Sciences

High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation

Massimiliano Ruscica et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

A Mendelian randomization study of the effects of blood lipids on breast cancer risk

Christoph Nowake et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Medicine, General & Internal

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

G. G. Schwartz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Medicine, General & Internal

Impact of PCSK9 loss-of-function genotype on 1-year mortality and recurrent infection in sepsis survivors

Kelly Roveran Genga et al.

EBIOMEDICINE (2018)

添加到收藏夹

Article Oncology

Hepatocellular carcinoma-associated hypercholesterolemia: involvement of proprotein-convertase-subtilisin-kexin type-9 (PCSK9)

Dipti Athavale et al.

CANCER & METABOLISM (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice

Christine Landlinger et al.

EUROPEAN HEART JOURNAL (2017)

添加到收藏夹

Article Medicine, General & Internal

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Marc S. Sabatine et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Inhibition of PCSK9 protects against radiation-induced damage of prostate cancer cells

Si-Shun Gan et al.

ONCOTARGETS AND THERAPY (2017)

添加到收藏夹

Article Medicine, Research & Experimental

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways

Xiaohui Xu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors to Reduce Cardiovascular Inflammation and Outcomes

Luca Liberale et al.

CURRENT MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

Giuseppe Danilo Norata et al.

CARDIOVASCULAR RESEARCH (2016)

添加到收藏夹

Article Immunology

Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis

John H. Boyd et al.

JOURNAL OF INNATE IMMUNITY (2016)

添加到收藏夹

Review Oncology

The multifaceted roles of fatty acid synthesis in cancer

Florian Roehrig et al.

NATURE REVIEWS CANCER (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Decreased PCSK9 expression in human hepatocellular carcinoma

Mamatha Bhat et al.

BMC GASTROENTEROLOGY (2015)

添加到收藏夹

Article Oncology

Plasma lipid levels and colorectal adenoma risk

John-Anthony Coppola et al.

CANCER CAUSES & CONTROL (2015)

添加到收藏夹

Article Oncology

Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells

Mohammad Hassan Naseri et al.

CANCER CELL INTERNATIONAL (2015)

添加到收藏夹

Article Immunology

A cholesterol-lowering VLP vaccine that targets PCSK9

Erin Crossey et al.

VACCINE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Peptide-Based Anti-PCSK9 Vaccines - An Approach for Long-Term LDLc Management

Gergana Galabova et al.

PLOS ONE (2014)

添加到收藏夹

Article Biochemical Research Methods

SILAC-based quantitative proteomic analysis of gastric cancer secretome

Arivusudar Marimuthu et al.

PROTEOMICS CLINICAL APPLICATIONS (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice

Elena Fattori et al.

JOURNAL OF LIPID RESEARCH (2012)

添加到收藏夹

Article Oncology

Proprotein Convertase Subtilisin/Kexin Type 9 Deficiency Reduces Melanoma Metastasis in Liver

Xiaowei Sun et al.

NEOPLASIA (2012)

添加到收藏夹

Article Pathology

Role of Cholesterol in the Development and Progression of Breast Cancer

Gemma Llaverias et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

添加到收藏夹

Article Gastroenterology & Hepatology

Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition

Franzel J. B. van Duijnhoven et al.

GUT (2011)

添加到收藏夹

Article Oncology

Low-Density Lipoprotein Cholesterol and the Risk of Cancer: A Mendelian Randomization Study

Marianne Benn et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2011)

添加到收藏夹

Article Hematology

Circulating Proprotein Convertase Subtilisin Kexin Type 9 Has a Diurnal Rhythm Synchronous With Cholesterol Synthesis and Is Reduced by Fasting in Humans

Lena Persson et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

添加到收藏夹

Letter Cardiac & Cardiovascular Systems

Commentary PCSK9 variants: A new database

Sarah E. A. Leigha et al.

ATHEROSCLEROSIS (2009)

添加到收藏夹

Article Endocrinology & Metabolism

Genetic and Metabolic Determinants of Plasma PCSK9 Levels

Susan G. Lakoski et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

添加到收藏夹

Review Medicine, General & Internal

The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis

S. A. Mousavi et al.

JOURNAL OF INTERNAL MEDICINE (2009)

添加到收藏夹

Article Oncology

Sequence variation in proprotein convertase subtilisin/kexin type 9 serine protease gene, low LDL cholesterol, and cancer incidence

Aaron R. Folsom et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

P Costet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

Review Biochemistry & Molecular Biology

Proprotein convertases: Master switches in the regulation of tumor growth and progression

DE Bassi et al.

MOLECULAR CARCINOGENESIS (2005)

添加到收藏夹

Article Multidisciplinary Sciences

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation

NG Seidah et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.