Anti-tumor effects of Curcuminoids in Glioblastoma Multiforme : An Updated Literature Review

Glioblastoma Multiforme (GBM) is a poorly curable brain tumor because of its extremely invasive nature. Curcuminoids, as potential phytochemicals extracted from Curcuma Longa L., have been documented for their chemopreventive and antitumor activities against several types of malignancies. These compounds exert these effects via modulation of multiple signaling pathways and molecular targets at different stages of tumor progression, proliferation, and metastasis. In experimental studies, curcuminoids have demonstrated promising therapeutic benefits to overcome GBM. Curcuminoids have been shown to exert their anti-GBM effects through regulation of angiogenesis, ing receptor tyrosine kinases, Sonic Hedgehog, and NF-kappa B. This study reviews the observations regarding the impact of curcumin and its derivatives on GBM and the potential of translating the research findings into the clinic.

Automated summary

Curcuminoids, extracted from Curcuma Longa, have shown promising therapeutic benefits in experimental studies against GBM by modulating various signaling pathways and molecular targets. They exert anti-GBM effects through regulation of angiogenesis, receptor tyrosine kinases, Sonic Hedgehog, and NF-kappa B, suggesting their potential for clinical translation.