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Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury

期刊

CURRENT MEDICINAL CHEMISTRY
卷 29, 期 19, 页码 3392-3419

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867328666210923143713

关键词

Traumatic brain injury; neurogenesis; hippocampus; models; animal; dentate gyrus; therapeutics

资金

  1. 2016 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation [25414]
  2. For Women in Science from L'oreal-Unesco-Academia Brasileira de Ciencias
  3. CNPq
  4. CAPES
  5. FAPEMIG

向作者/读者索取更多资源

Traumatic brain injury is a serious cause of disability and death, and neurogenesis may provide potential benefits for its treatment.
Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI's long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.

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