期刊
CURRENT DRUG TARGETS
卷 23, 期 7, 页码 729-751出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450123666220117104038
关键词
Neurological disorders; arylpiperazines; Alzheimer's disease; Parkinson's disease; depression; curative agents
资金
- Council of Scientific and Industrial Research, New Delhi [02/(0354)/19/EMRII]
Neurological disorders are related to abnormalities in neurons and the central nervous system. Current medicines only provide symptomatic relief. Arylpiperazine has been found to be an important pharmacophore in CNS active agents and can be used to design drugs for various neurological disorders.
Neurological disorders are disease conditions related to the neurons and central nervous system (CNS). Any structural, electrical, biochemical, and functional abnormalities in neurons can lead to various types of disorders, like Alzheimer's disease (AD), depression, Parkinson's disease (PD), epilepsy, stroke, etc. Currently available medicines are symptomatic and do not treat the disease state. Thus, novel CNS active agents with the potential to completely treat an illness are highly desired. A range of small organic molecules is being explored as potential drug candidates to cure different neurological disorders. In this context, arylpiperazinehas been found to be a versatile scaffold and indispensable pharmacophore in many CNS active agents. Several molecules with arylpiperazine nucleus have been developed as potent leads for the treatment of AD, PD, depression, and other disorders. The arylpiperazine nucleus can be optionally substituted at different chemical structures and offer flexibility for the synthesis of a large number of derivatives. In the current review article, we have explored the role of various arylpiperazine containing scaffolds against different neurological disorders, including AD, PD, and depression. The structure-activity relationship studies were conducted for recognizing potent lead compounds. This review article may provide important insights into the structural requirements for designing and synthesizing effective molecules as curative agents for different neurological disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据