期刊
CURRENT BIOLOGY
卷 32, 期 2, 页码 304-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2021.11.004
关键词
-
资金
- NIH [F31MH124360, R01EY028746, R01MH122387and R00MH106719]
Research has shown that competing experiences of fear and extinction are stored as distinct memory traces in the brain. This divided organization is important for preventing overgeneralization of fear and maintaining threat associations. However, the mechanisms involved in organizing these memories in the human brain are still unclear.
Neurobiological research in rodents has revealed that competing experiences of fear and extinction are stored as distinct memory traces in the brain. This divided organization is adaptive for mitigating overgeneralization of fear to related stimuli that are learned to be safe while also maintaining threat associations for unsafe stimuli. The mechanisms involved in organizing these competing memories in the human brain remain unclear. Here, we used a hybrid form of Pavlovian conditioning with an episodic memory component to identify overlapping multivariate patterns of fMRI activity associated with the formation and retrieval of fear versus extinction. In healthy adults, distinct regions of the medial prefrontal cortex (PFC) and hippocampus showed selective reactivation of fear versus extinction memories based on the temporal context in which these memories were encoded. This dissociation was absent in participants with posttraumatic stress disorder (PTSD) symptoms. The divided neural organization of fear and extinction may support flexible retrieval of context-appropriate emotional memories, while their disorganization may promote overgeneralization and increased fear relapse in affective disorders.
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