期刊
CURRENT BIOLOGY
卷 32, 期 4, 页码 796-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2021.12.039
关键词
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资金
- Direccion General de Asuntos del Personal Acade?mico grant (DGAPA) [IG-201321]
- Consejo Nacional de Ciencia y Tecnologa (CONACyT) -QUEBEC [279293]
- CONACyT [646866/626173]
This study reveals that the biological clock regulates the day-night variations in blood glucose levels through the release of vasopressin and the promotion of glucose entrance into the arcuate nucleus via GLUT1 transporter.
Glycemia is maintained within very narrow boundaries with less than 5% variation at a given time of the day. However, over the circadian cycle, glycemia changes with almost 50% difference. How the suprachiasmatic nucleus, the biological clock, maintains these day-night variations with such tiny disparities remains obscure. We show that via vasopressin release at the beginning of the sleep phase, the suprachiasmatic nucleus increases the glucose transporter GLUT1 in tanycytes. Hereby GLUT1 promotes glucose entrance into the arcuate nucleus, thereby lowering peripheral glycemia. Conversely, blocking vasopressin activity or the GLUT1 transporter at the daily trough of glycemia increases circulating glucose levels usually seen at the peak of the rhythm. Thus, biological clock-controlled mechanisms promoting glucose entry into the arcuate nucleus explain why peripheral blood glucose is low before sleep onset.
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