期刊
CURRENT BIOLOGY
卷 31, 期 22, 页码 R1491-R1504出版社
CELL PRESS
DOI: 10.1016/j.cub.2021.09.083
关键词
-
资金
- NIH [R35 GM131868]
The centromere plays a crucial role in accurately segregating genetic information during cell division. However, the mechanisms of centromere specification vary among different species and cell types, making the identification of a universal mechanism challenging.
The centromere performs a universally conserved function, to accurately partition genetic information upon cell division. Yet, centromeres are among the most rapidly evolving regions of the genome and are bound by a varying assortment of centromere-binding factors that are themselves highly divergent at the protein sequence level. A common thread in most species is the dependence on the centromere-specific histone variant CENP-A for the specification of the centromere site. However, CENP-A is not universally required in all species or cell types, making the identification of a general mechanism for centromere specification challenging. In this review, we examine our current understanding of the mechanisms of centromere specification in CENP-A-dependent and independent systems, focusing primarily on recent work.
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