期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 168, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2021.103522
关键词
Polycyclic aromatic hydrocarbon; Meat; Colon; Rectal; Bowel; Cancer; Carcinoma; Diet
Polycyclic aromatic hydrocarbons (PAHs) are molecules that contaminate meat products during high-temperature cooking and are associated with colorectal cancer. PAHs promote the development of colorectal cancer through mechanisms such as DNA damage. Research on genetic polymorphisms suggests a potential link between PAH-meat intake and carcinogenesis of colorectal malignancies.
Polycyclic aromatic hydrocarbon (PAHs) are molecules that contaminate meat products during the hightemperature cooking of meat. This study reviewed the pathogenic roles of meat derived polycyclic aromatic hydrocarbons in the carcinogenesis of colorectal cancer (CRC). Ingested PAHs undergo xenobiotic metabolism resulting in the activation of genotoxic metabolites that can induce DNA damage in the colorectum. Genetic polymorphisms in PAH xenobiotic enzymes are linked to the risk of CRC and suggest a role for PAH-meat ingestion in carcinogenesis of colorectal malignancies. Furthermore, PAH specific DNA adducts have been identified in colorectal cancer tissue and linked to high meat intake. DNA adduct resolution is mediated by the nucleotide excision repair, and polymorphisms within genes of this repair pathway and high meat intake are associated with increased CRC risk. In the literature, there is evidence from metabolic enzyme gene variants, DNA repair genes, PAH metabolites, and epidemiological studies suggesting PAH involvement in CRC.
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