期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 63, 期 23, 页码 6285-6308出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2022.2030296
关键词
Gastrointestinal disorder; gut microbiota; inflammation; metabolism; proanthocyanidins
This review discusses the beneficial effects of dietary proanthocyanidins (PAC) on gastrointestinal functions. The findings suggest that PAC can directly act on the gastrointestinal tract through its antioxidant, antibacterial, anti-inflammatory, and anti-proliferative properties. PAC can also interact with carbohydrates, proteins, and lipids, reducing their digestion and absorption. Additionally, PAC has a prebiotic-like effect on the intestinal microbiota, which may contribute to the potential health benefits.
Many epidemiological and experimental studies have consistently reported the beneficial effects of dietary proanthocyanidins (PAC) on improving gastrointestinal physiological functions. This review aims to present a comprehensive perspective by focusing on structural properties, interactions and gastrointestinal protection of PAC. In brief, the main findings of this review are summarized as follows: (1) Structural features are critical factors in determining the bioavailability and subsequent pharmacology of PAC; (2) PAC and/or their bacterial metabolites can play a direct role in the gastrointestinal tract through their antioxidant, antibacterial, anti-inflammatory, and anti-proliferative properties; (3) PAC can reduce the digestion, absorption, and bioavailability of carbohydrates, proteins, and lipids by interacting with them or their according enzymes and transporters in the gastrointestinal tract; (4). PAC showed a prebiotic-like effect by interacting with the microflora in the intestinal tract, and the enhancement of PAC on a variety of probiotics, such as Bifidobacterium spp. and Lactobacillus spp. could be associated with potential benefits to human health. In conclusion, the potential effects of PAC in prevention and alleviation of gastrointestinal diseases are remarkable but clinical evidence is urgently needed.
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