期刊
CRITICAL REVIEWS IN BIOTECHNOLOGY
卷 43, 期 2, 页码 293-308出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07388551.2021.2010645
关键词
Phenyllactic acid; phenylalanine; phenylpyruvic acid; antimicrobial; preservative; metabolic pathway and biosynthesis
Phenyllactic acid (PLA) has broad-spectrum antimicrobial properties and is widely used in the field of food safety. This article provides updates on the recent developments in the production of PLA through microbial fermentation and whole-cell catalysis strategies. It covers the physicochemical properties, inhibition spectrum, antimicrobial mechanisms, production factors, and applications of PLA.
Phenyllactic acid (PLA) is capable of inhibiting the growth of many microorganisms, showing a broad-spectrum antimicrobial property, which allows it to hold vast applications in the: food, feed, pharmaceutical, and cosmetic industries, especially in the field of food safety. Recently, the production of PLA has garnered considerable attention due to the increasing awareness of food safety from the public. Accordingly, this review mainly updates the recent development for the production of PLA through microbial fermentation and whole-cell catalysis (expression single-, double-, and triple-enzyme) strategies. Firstly, the: physicochemical properties, existing sources, and measurement methods of PLA are systematically covered. Then, the inhibition spectrum of PLA is summarized, and synchronously, the antimicrobial and anti-biofilm mechanisms of PLA on commonly pathogenic microorganisms in foods are described in detail, thereby clarifying the reason for extending the shelf life of foods. Additionally, the factors affecting the production of PLA are summarized from the biosynthesis and catabolism pathway of PLA in microorganisms, as well as external environmental parameters insights. Finally, the downstream treatment process and applications of PLA are discussed and outlined. In the future, clinical data should be supplemented with the metabolic kinetics of PLA in humans and to evaluate animal toxicology, to enable regulatory use of PLA as a food additive. A food-grade host, such as Bacillus subtilis and Lactococcus lactis, should also be developed as a cell vector expressing enzymes for PLA production from a food safety perspective.
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