期刊
CORTEX
卷 145, 期 -, 页码 1-12出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.cortex.2021.09.007
关键词
Stroke; Lesion anatomy; Lesion-deficit prediction; Dimensionality reduction; Brain imaging
资金
- Wellcome Trust
- UCLH NIHR Biomedical Research Centre
Cognitive and behavioral outcomes after stroke are influenced by the functional organization of the brain and the structural distribution of ischaemic injury. High-dimensional methods can provide better predictive fidelity than low-dimensional methods, but require large data scales.
Cognitive and behavioural outcomes in stroke reflect the interaction between two complex anatomically-distributed patterns: the functional organization of the brain and the structural distribution of ischaemic injury. Conventional outcome models-for individual prediction or population-level inference-commonly ignore this complexity, discarding anatomical variation beyond simple characteristics such as lesion volume. This sets a hard limit on the maximum fidelity such models can achieve. High-dimensional methods can overcome this problem, but only at prohibitively large data scales. Drawing on one of the largest published collections of anatomically-registered imaging of acute stroke-N = 1333-here we use non-linear dimensionality reduction to derive a succinct latent representation of the anatomical patterns of ischaemic injury, agglomerated into 21 distinct intuitive categories. We compare the maximal predictive performance it enables against both simpler low-dimensional and more complex high-dimensional representations, employing multiple empirically-informed ground truth models of distributed structure-outcome relationships. We show our representation sets a substantially higher ceiling on predictive fidelity than conventional low-dimensional approaches, but lower than that achievable within a high-dimensional framework. Where descriptive simplicity is a necessity, such as within clinical care or research trials of modest size, the representation we propose arguably offers a favourable compromise of compactness and fidelity. (C) 2021 The Author(s). Published by Elsevier Ltd.
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