Causal dynamics and information flow in parietal- temporal-hippocampal circuits during mental arithmetic revealed by high-temporal resolution human intracranial EEG

Mental arithmetic involves distributed brain regions spanning parietal and temporal cortices, yet little is known about the neural dynamics of causal functional circuits that link them. Here we use high-temporal resolution (1000 Hz sampling rate) intracranial EEG from 35 participants, 362 electrodes, and 1727 electrode pairs, to investigate dynamic causal circuits linking posterior parietal cortex (PPC) with ventral temporal-occipital cortex and hippocampal regions which constitute the perceptual, visuospatial, and mnemonic building blocks of mental arithmetic. Nonlinear phase transfer entropy measures capable of capturing information flow identified dorsal PPC as a causal inflow hub during mental arithmetic, with strong causal influences from fusiform gyrus in ventral temporal-occipital cortex as well as the hippocampus. Net causal inflow into dorsal PPC was significantly higher during mental arithmetic, compared to both resting-state and verbal memory recall. Our analysis also revealed functional heterogeneity of casual signaling in the PPC, with greater net causal inflow into the dorsal PCC, compared to ventral PPC. Additionally, the strength of causal influences was significantly higher on dorsal, compared to ventral, PPC from the hippocampus, and ventral temporal-occipital cortex during mental arithmetic, when compared to both resting-state and verbal memory recall. Our findings provide novel insights into dynamic neural circuits and hubs underlying numerical problem solving and reveal neurophysiological circuit mechanisms by which both the visual number form processing and declarative memory systems dynamically engage the PPC during mental arithmetic.(c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

In this study, high-temporal resolution intracranial EEG was used to investigate the neural dynamics of causal functional circuits during mental arithmetic. The results revealed the involvement of posterior parietal cortex (PPC) as a causal inflow hub, with strong causal influences from ventral temporal-occipital cortex and hippocampus. The analysis also showed functional heterogeneity of casual signaling in the PPC, with greater net causal inflow into the dorsal PCC. The findings provide insights into the neural circuits underlying numerical problem solving during mental arithmetic.