期刊
COORDINATION CHEMISTRY REVIEWS
卷 446, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2021.214114
关键词
Two-photon fluorescence; Ratiometric; Biological sensing; Biological imaging; Biomedicine
资金
- Natural Science Foundation of Shandong, China [ZR2019MB026]
- Source Innovation Plan Application Basic Research Project of Qingdao, China [18-2-2-26-jch]
This review summarizes recent advances in RTPF probes and their potential applications, focusing on design, principles, targets, samples, sensing mechanisms, bioimaging, and biomedical applications. It also discusses current states, challenges, and future perspectives in various aspects of RTPF probes for potential clinical therapy in malignant diseases and cancers.
The unique two-photon excitable luminescence and dual-emission ratio output features endow organic molecule-based ratiometric two-photon fluorescence (RTPF) probes as powerful and versatile analysis tools with promising biological and biomedical applications, especially in target biosensing, bioimaging and biomedicine therapy in live cells, subcellular organelles, in-vivo deep tissues or organs. To further facilitate the ever-increasing studies on high- performance RTPF probes for important bio-applications in recent years, a timely and comprehensive review is still unavailable and it is highly expected for researches in multiple fields due to scientific urgency and necessity. In this context, this review systematically summarizes the recent advances in RTPF probes through thoroughly analyzing numerous studies published during the past decade. The review focuses on crucial aspects of RTPF probes, mainly referring to computational designs, construction principles, targets, bio-samples, sensing mechanisms, biosensing, bioimaging and biomedical applications, combination with other sensing methods, imaging modes and biomedicine therapy strategies at the living cell and small animal levels, biological toxicity, in-vivo distribution, etc. This review summarizes and discusses the state-of-the-art relevant studies about RTPF probes in various aspects, and rationally comments current states, probable challenges and perspectives in forthcoming studies. This present review is highly attractive for numerous researchers from multiple discipline fields and promotes the exploration of multifunctional and targeting therapeutic agents that have excellent performances in target biosensing, bioimaging and biomedicine applications in vitro and in vivo, and exhibit great prospects in early screening, precise diagnosis and clinic therapy of malignant diseases and cancers. (C) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据