期刊
COORDINATION CHEMISTRY REVIEWS
卷 446, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2021.214133
关键词
Lanthanides; Redox; Probes; Contrast agents; Luminescence; Non-innocent ligands
资金
- French National Research Agency [ANR-15IDEX-02]
- Labex ARCANE, CBH-EUR-GS [ANR-17-EURE-0003]
- ANR Co-Lantha [ANR-17-CE07-0034]
- Agence Nationale de la Recherche (ANR) [ANR-17-CE07-0034] Funding Source: Agence Nationale de la Recherche (ANR)
Lanthanides complexes are widely used in medicine and biology due to their unique properties for magnetic resonance imaging and luminescence. Recent advances in utilizing redox-reactive ligands have overcome the limitations of lanthanides in redox monitoring, expanding their applications in detecting biological relevant ROS, RNS and redox status.
Lanthanides complexes are indispensable in fields related to medicine and biology. Their success lies in the great number of unpaired electrons (4f(7) configuration of the Gd3+ ion) that makes them ideal contrasts agents for magnetic resonance imaging. On the other hand their narrow emission bands and long lifetime of their excited state provide them unique luminescence properties. The aqueous solution chemistry of the lanthanides is dominated by the (+III) oxidation state under oxygenated atmosphere. This severely limits their use as redox probes, and not surprisingly very few redox-switches employing lanthanide ions were reported until 2010. A very promising approach based on redox-reactive and redox non-innocent ligands has recently emerged in the literature, which overcomes this limitation and expands the application of lanthanides to redox monitoring. Herein the ligand acts as a redox-sensor by either changing its oxidation state or reacting with reactive oxygen (or nitrogen) species (ROS/RNS). Its response induces changes in the environment of the lanthanide ion, which acts as a reporter of the redox status. The detection is based on a modification of the magnetic or optical properties of the complexes, with detection by conventional spectroscopic techniques. We summarize in this review article the recent advances in this burgeoning field, with special emphasis on the detection of biological relevant ROS, RNS and redox status. (C) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据