Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Hypochlorous acid is an endogenously produced reactive oxygen species that plays a crucial role in various diseases. Sulfur-based fluorescent probes for HOCl have shown excellent performance in terms of rapid reaction rate, high selectivity, and sensitivity, which are essential for better understanding the role of HOCl in chemical biology.