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Seeing the unseen: AIE luminogens for super-resolution imaging

期刊

COORDINATION CHEMISTRY REVIEWS
卷 451, 期 -, 页码 -

出版社

ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2021.214279

关键词

Aggregation-induced emission; Super-resolution imaging; Fluorescence imaging; Organic fluorophores; Abbe's diffraction limit

资金

  1. National Natural Science Foundation of China [21975197, 21674085, 51603165]
  2. Young Talent Fund of University Association for Science and Technology in Shaanxi, China [20180601]
  3. Key Laboratory Construction Program of Xi'an Municipal Bureau of Science and Technology [201805056ZD7CG40]
  4. Innovation Capability Support Program of Shaanxi [2021TD-57, 2018PT-28, 2019PT-05]

向作者/读者索取更多资源

This paper summarizes the important role and application of aggregation-induced emission luminogens (AIEgens) in super-resolution imaging (SRI). By introducing the working principles of AIEgens and SRI techniques, it highlights their excellent performance and prospects.
Super-resolution imaging (SRI) is of great significance to break the Abbe's diffraction limit, enabling visualization and dynamic monitoring with ultra-high resolution in both material science and biology. Fluorophores play an important role in SRI. Among them, aggregation-induced emission (ALE) luminogens (AIEgens) are one of the most promising imaging agents for SRI. They are easy to be synthesized and possess high tailoring ability, high brightness in aggregated states, large Stokes' shift, good photostability, and also excellent biocompatibility. Based on this consideration, the recent progress on AIEgens for SRI is summarized here. The working principles of AIEgens and several SRI techniques are also introduced to illustrate the material requirements. The new achievements in AIEgens research for SRI, including their chemical structures, optical properties, and applications, are highlighted in detail. The goal is to provide the readers with an overview of the recent advances in AIEgens for SRI. It is also anticipated that a deep understanding of the relationship between the AIEgens' properties and their imaging performance can be obtained. This review also aims to provide a set of guidelines to develop new AIEgens for fluorescence imaging to achieve superior resolution, thus resulting a better understanding of their mechanism in both biology and material science. (C) 2021 Elsevier B.V. All rights reserved.

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