☆ 4.7 Review

An updated review on food-derived bioactive peptides: Focus on the regulatory requirements, safety, and bioavailability

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2022)

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Article Chemistry, Applied

Flavor mystery of Chinese traditional fermented baijiu: The great contribution of ester compounds

Youqiang Xu et al.

Summary: Chinese traditional fermented baijiu is a famous alcoholic beverage with a unique flavor profile, mainly due to the contribution of esters, particularly ethyl esters. Various microbial species affect the synthesis of esters through fatty acid and amino acid metabolism, influencing the final taste of baijiu. Understanding the mechanism of baijiu flavor formation is crucial for ensuring reproducible flavor profile.

FOOD CHEMISTRY (2022)

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Article Chemistry, Applied

Identification of novel antihypertensive peptides from wine lees hydrolysate

Francisca Isabel Bravo et al.

Summary: Enzymatic-assisted extraction using Flavourzyme (R) was used to obtain wine lees enriched in phenolic compounds with enhanced antihypertensive activity. The study identified six peptides with antihypertensive activity, three of which had ACEi values lower than 20 mu M, indicating their potential as functional ingredients for managing hypertension. The peptides FKTTDQQTRTTVA, NPKLVTIV, TVTNPARIA, LDSPSEGRAPG, and LDSPSEGRAPGAD exhibited antihypertensive activity in spontaneously hypertensive rats.

FOOD CHEMISTRY (2022)

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Article Agriculture, Multidisciplinary

Hypoglycemic peptide-enriched hydrolysates of Corbicula fluminea and Chlorella sorokiniana possess synergistic hypoglycemic activity through inhibiting α-glucosidase and dipeptidyl peptidase-4 activity

Tse-Hung Huang et al.

Summary: The prevalence of diabetes worldwide has been increasing in recent decades. This study focused on investigating the hypoglycemic activity of a combination of hypoglycemic peptide-enriched hydrolysates of Corbicula fluminea (ACH) and Chlorella sorokiniana (PCH). The results showed that combined supplementation of ACH and PCH could synergistically inhibit alpha-glucosidase and DPP4 activities, leading to a decrease in blood glucose levels and insulin resistance.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

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Article Food Science & Technology

Peptide fraction from sturgeon muscle by pepsin hydrolysis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages via MAPK and NF-κB pathways

Ruichang Gao et al.

Summary: The study investigated the anti-inflammatory potential of sturgeon peptides, finding that they significantly reduce the expression of inflammatory mediators and cytokines while also displaying strong antioxidant effects. The peptides exert their anti-inflammatory influence by inhibiting MAPK and NF-kappa B pathways.

FOOD SCIENCE AND HUMAN WELLNESS (2021)

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Article Chemistry, Applied

Anti-inflammatory and antioxidant effects of peptides released from germinated amaranth during in vitro simulated gastrointestinal digestion

Eslim Sugey Sandoval-Sicairos et al.

Summary: This study identified bioactive peptides, especially anti-inflammatory ones, released from germinated amaranth during in vitro gastrointestinal digestion, showing potential for combating non-communicable diseases.

FOOD CHEMISTRY (2021)

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Article Food Science & Technology

In vitro antihypertensive activity of bioactive peptides derived from porcine blood corpuscle and plasma proteins

Panida Aiemratchanee et al.

Summary: New bioactive peptides with antihypertensive properties were identified from porcine blood, showing potential in the treatment of high blood pressure.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2021)

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Review Chemistry, Applied

Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review

Muhammad Usman et al.

Summary: The hydrophobically modified inulin (HMI) has gained attention for its multiple features. The review discusses the limitations of SCFAs inulin esters, real food dispersion formulations, and HMI drugs. The results show the potential of HMI as an excipient for hydrophobic drugs.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

The Anticancer Peptide CIGB-552 Exerts Anti-Inflammatory and Anti-Angiogenic Effects through COMMD1

Hellen Daghero et al.

Summary: The study revealed the important role of COMMD1 in the mechanism of action of CIGB-552 by knocking out COMMD1 and analyzing the cell lines with microarray, validating signaling pathways to confirm the results. The findings showed that CIGB-552 inhibits the expression of related genes in lung cancer cell lines by modulating NF-kB and HIF-1 signaling pathways.

MOLECULES (2021)

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Article Chemistry, Applied

Antimicrobial peptides purified from hydrolysates of kanihua (Chenopodium pallidicaule Aellen) seed protein fractions

Gladys Moscoso-Mujica et al.

Summary: The study aimed to obtain purified bioactive antimicrobial peptides from two varieties of kanihua and investigate their inhibition effects on E. coli, S. aureus, and C. albicans growth. Experimental results showed that 4 AMPs with significant inhibition rates were obtained from the hydrolysates.

FOOD CHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria

Ningyi Zhu et al.

Summary: Newly designed peptides with excellent bioactivity, modest cell toxicity, low resistance tendency, and moderate stability have been developed through amino acid substitution and peptide truncation. These peptides demonstrate synergy or additive effects against Gram-negative bacteria when combined with conventional antibiotics, showing promise as antibiotic alternatives to tackle the risk of drug-resistant Gram-negative bacteria.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Chemistry, Applied

Simulated gastrointestinal digestion of camel and bovine casein hydrolysates: Identification and characterization of novel anti-diabetic bioactive peptides

Priti Mudgil et al.

Summary: Camel and bovine camel casein hydrolysates demonstrate potent antidiabetic effects in vitro by inhibiting various enzymes. Specific peptides identified in these hydrolysates may play a key role in their inhibitory properties, suggesting their potential use as functional antidiabetic agents in food formulations.

FOOD CHEMISTRY (2021)

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Article Chemistry, Applied

Identification of antioxidant peptides derived from tropical jackfruit seed and investigation of the stability profiles

Tsun-Thai Chai et al.

Summary: Jackfruit seed proteins were isolated, purified, and two antioxidant peptides were identified with potential for use as preservatives or health-promoting diet supplements.

FOOD CHEMISTRY (2021)

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Article Chemistry, Applied

Baijiu vinasse as a new source of bioactive peptides with antioxidant and anti-inflammatory activity

Lin Peng et al.

Summary: By utilizing alkaline extraction and ultra-sonication to recover proteins from baijiu vinasse, and hydrolyzing them with Corolase PP, peptide fractions with high DPPH radical scavenging activity were obtained. VPH-3, especially under 3 kDa after ultrafiltration, exhibited lower EC50 values for ROS and RNS radicals compared to VPH-1 and VPH-2, and showed significant inhibition of NO and pro-inflammatory cytokines in LPS-stimulated RAW264.7 macrophage cells. LC-MS/MS analysis identified active peptides with strong anti-inflammatory activity, such as KLPDHPKLPK and VDVPVKVPYS, at a concentration of 0.25 mg/mL. These findings suggest potential for commercial development of baijiu vinasse as a new source of bioactive peptides.

FOOD CHEMISTRY (2021)

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Review Chemistry, Medicinal

Functional and Bioactive Properties of Peptides Derived from Marine Side Streams

Ilknur Ucak et al.

Summary: In fish processing, side streams such as skin, bones, heads and viscera are rich sources of protein and bioactive nitrogenous compounds, which can be converted into peptides through enzymatic hydrolysis and bacterial fermentation. These peptides have applications as preservatives, antioxidants, and in modifying food ingredient properties for functional foods and nutraceuticals in the food and pharmaceutical industries.

MARINE DRUGS (2021)

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Article Food Science & Technology

HPP and SGQR peptides from silkworm pupae protein hydrolysates regulated biosynthesis of cholesterol in HepG2 cell line

Suling Sun et al.

Summary: Peptides with high HMGCR inhibitory activity were screened from silkworm pupae protein hydrolysates, and in vitro studies confirmed HPP and SGQR as inhibitors of HMGCR. Molecular docking revealed key interactions responsible for their role in improving hypercholesterolemia, suggesting potential therapeutic benefits.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Food Science & Technology

Xylo-oligosaccharides ameliorate high cholesterol diet induced hypercholesterolemia and modulate sterol excretion and gut microbiota in hamsters

Abdullah Abdulaziz Abbod Abdo et al.

Summary: The study showed that xylo-oligosaccharides can significantly reduce plasma cholesterol levels by increasing the excretion of neutral and acidic sterols and promoting the production of SCFAs. Additionally, dietary supplementation with xylo-oligosaccharides can alter the composition of gut microbiota.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Food Science & Technology

The antihypertensive effect and mechanisms of bioactive peptides from Ruditapes philippinarum fermented with Bacillus natto in spontaneously hypertensive rats

Yahui Song et al.

Summary: The study demonstrated that RBPs have significant antihypertensive effects in spontaneously hypertensive rats, as well as the ability to improve heart, kidney, and vascular damage, regulate related signaling pathways, and enhance gut microbiota.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Article Nutrition & Dietetics

Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet

Xiao-Yue Yang et al.

Summary: The study found that walnut meal peptides can effectively counteract the negative effects of a high-fat diet on body weight, lipid metabolism, and liver fat content in rats, indicating its potential in preventing atherosclerosis.

NUTRIENTS (2021)

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Article Microbiology

A Novel Antimicrobial Peptides From Pine Needles of Pinus densiflora Sieb. et Zucc. Against Foodborne Bacteria

Junho Lee et al.

Summary: Pine needles contain functional components with antioxidant, antimicrobial, anti-diabetic, and anti-inflammatory activities. Novel antimicrobial peptides isolated from Pinus densiflora Sieb. et Zucc. showed antimicrobial activity against foodborne bacteria without hemolytic activity or cytotoxicity, suggesting potential applications in the food industry.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Chemistry, Applied

Preparation and identification of antioxidant peptides from cottonseed proteins

Liying Wang et al.

Summary: The study revealed that cottonseed peptides prepared by enzymatic hydrolysis and microbial fermentation possess antioxidant properties, especially when the molecular weight is less than 3 kDa. The cottonseed protein hydrolysates are rich in specific amino acids, and certain peptides interact with the binding site of Keap1-Nrf2 interaction, indicating potential as functional ingredients in food products.

FOOD CHEMISTRY (2021)

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Review Chemistry, Applied

Recently isolated food-derived antihypertensive hydrolysates and peptides: A review

Arshdeep Kaur et al.

Summary: Bioactive peptides from food sources have shown potential as therapeutic agents for hypertension by inhibiting ACE and reducing blood pressure. Research has focused on the isolation, hydrolysis, and biofunctionality testing of these peptides, providing valuable literature for hypertension treatment.

FOOD CHEMISTRY (2021)

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Article Chemistry, Applied

Generation of antimicrobial peptides Leg1 and Leg2 from chickpea storage protein, active against food spoilage bacteria and foodborne pathogens

Marie-Louise Heymich et al.

Summary: By hydrolyzing the storage protein legumin extracted from chickpea, novel antimicrobial peptides Leg1 and Leg2 were developed, exhibiting high antimicrobial activity against a wide range of bacteria, including pathogens and antibiotic-resistant strains. These peptides showed bactericidal activity and were 10-1,000-fold more active compared to conventional food preservatives.

FOOD CHEMISTRY (2021)

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Article Food Science & Technology

Effects of incorporating different kinds of peptides on the foaming properties of egg white powder

Tingting Tang et al.

Summary: The study found that adding soy peptides, corn peptides, and fish skin peptides can improve the foaming properties of egg white powder, and significantly increase the elastic modulus of the foam.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2021)

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Article Multidisciplinary Sciences

Properties of peptides released from salmon and carp via simulated human-like gastrointestinal digestion described applying quantitative parameters

Justyna Borawska-Dziadkiewicz et al.

Summary: Bioactive peptides from salmon and carp proteins were studied using in silico analysis, showing that myofibrillar proteins of these fishes have the potential to release ACE inhibitors and antioxidant peptides. Peptides obtained after digestion were evaluated for bioactivity potential and safety properties, with a high probability of absorption and low toxicity being notable advantages.

PLOS ONE (2021)

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Article Nutrition & Dietetics

Anti-Obesity and Hypocholesterolemic Actions of Protamine-Derived Peptide RPR (Arg-Pro-Arg) and Protamine in High-Fat Diet-Induced C57BL/6J Mice

Maihemuti Mijiti et al.

Summary: The study reported a novel anti-obesity and hypocholesterolemic peptide, RPR, derived from protamine in mice fed a high-fat diet. Results showed that protamine and RPR can lower serum cholesterol levels, decrease white adipose tissue weight, and increase fecal excretion of cholesterol and bile acid.

NUTRIENTS (2021)

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Article Chemistry, Physical

Production and Purification of Novel Hypocholesterolemic Peptides from Lactic Fermented Spirulina platensis through High Hydrostatic Pressure-Assisted Protease Hydrolysis

Guan-Wen Chen et al.

Summary: This study focused on the proteolytic capacity of Spirulina platensis and successfully extracted peptides with inhibitory activity on HMGR through methods such as protease hydrolysis and high static pressure treatment, achieving the hypocholesterolemic effect of Spirulina platensis.

CATALYSTS (2021)

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Article Food Science & Technology

In silico analysis of novel dipeptidyl peptidase-IV inhibitory peptides released from Macadamia integrifolia antimicrobial protein 2 (MiAMP2) and the possible pathways involved in diabetes protection

Lei Zhao et al.

Summary: This study aimed to identify novel DPP-IV inhibitory peptides from Macadamia integrifolia antimicrobial protein 2 (MiAMP2) and evaluate their potential antidiabetic targets and signaling pathways using computational approaches. The results showed that AESE displayed strong DPP-IV inhibitory activity and could prevent diabetes through apoptosis and TNF signaling pathways, providing new insights into the potential use of MiAMP2 as functional food ingredients for diabetes prevention and treatment.

CURRENT RESEARCH IN FOOD SCIENCE (2021)

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Review Pharmacology & Pharmacy

Bioactive Peptides in Supplements and Functional Foods - A Commercial Perspective

Ragnhild Dragoy Whitaker et al.

Summary: Bioactive peptides from marine sources have great potential for development in the nutraceutical and functional food market, but commercialization requires addressing challenges related to commercial opportunities and consumer acceptance.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Review Food Science & Technology

Applications of soy protein hydrolysates in the emerging functional foods: a review

Tolulope Joshua Ashaolu

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2020)

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Article Food Science & Technology

Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice

Chengnan Zhang et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Review Food Science & Technology

Safety considerations on food protein-derived bioactive peptides

Ling Liu et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

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Article Food Science & Technology

Advances on the antioxidant peptides from edible plant sources

Fai-Chu Wong et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

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Review Polymer Science

Polymer bioconjugates: Modern design concepts toward precision hybrid materials

Chaojian Chen et al.

PROGRESS IN POLYMER SCIENCE (2020)

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Article Food Science & Technology

Role of using adjunct cultures in release of bioactive peptides in white-brined goat-milk cheese

Ali Kocak et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2020)

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Article Nutrition & Dietetics

Mapping Coeliac Toxic Motifs in the Prolamin Seed Storage Proteins of Barley, Rye, and Oats Using a Curated Sequence Database

Matthew Daly et al.

FRONTIERS IN NUTRITION (2020)

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Article Biochemistry & Molecular Biology

Artificial intelligence and machine learning for protein toxicity prediction using proteomics data

Shubham Vishnoi et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2020)

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Article Food Science & Technology

Low molecular weight blue mussel hydrolysates inhibit adipogenesis in mouse mesenchymal stem cells through upregulating HO-1/Nrf2 pathway

Yunok Oh et al.

FOOD RESEARCH INTERNATIONAL (2020)

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Review Food Science & Technology

Bioactive peptides derived from plant origin by-products: Biological activities and techno-functional utilizations in food developments - A review

Ahmet Gorguc et al.

FOOD RESEARCH INTERNATIONAL (2020)

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Article Food Science & Technology

Structure-activity relationship and pathway of antioxidant shrimp peptides in a PC12 cell model

Dan Wu et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Food Science & Technology

Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting alpha-glucosidase and alpha-amylase, and alleviating insulin resistance of hepatic HepG2 cells

Ji Wang et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Biochemistry & Molecular Biology

Exploring the antioxidant effects of peptides from almond proteins using PAni-Ag-GONC conjugated trypsin by improving enzyme stability & applications

Irfanah Siddiqui et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Food Science & Technology

Purification and identification of anti-allergic peptide from Atlantic Salmon (Salmo salar) byproduct enzymatic hydrolysates

Kexin Wang et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Food Science & Technology

Identification and molecular mechanism of angiotensin-convertingenzyme inhibitory peptides from Larimichthys crocea titin

Yue Fan et al.

FOOD SCIENCE AND HUMAN WELLNESS (2020)

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Review Food Science & Technology

Plant protein-derived antioxidant peptides: Isolation, identification, mechanism of action and application in food systems: A review

Chaoting Wen et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

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Article Genetics & Heredity

Construction, cloning, and expression of Melittin antimicrobial peptide using Pichia pastoris expression system

Khadijeh Moridi et al.

GENE REPORTS (2020)

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Article Biochemistry & Molecular Biology

Exploring the Role of a Novel Peptide from Allomyrina dichotoma Larvae in Ameliorating Lipid Metabolism in Obesity

Sung Mun Bae et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Yin Dou et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Medicine, Research & Experimental

Antimicrobial peptides - Advances in development of therapeutic applications

Huy Xuan Luong et al.

LIFE SCIENCES (2020)

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Review Multidisciplinary Sciences

Production and processing of antioxidant bioactive peptides: A driving force for the functional food market

Solomon Abebaw Tadesse et al.

HELIYON (2020)

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Article Agriculture, Dairy & Animal Science

Isolation and identification of angiotensin I-converting enzyme inhibitory peptides derived from thermolysin-injected beef M. longissimus

Juhui Choe et al.

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES (2019)

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Review Food Science & Technology

Bioactive peptides with antidiabetic properties: a review

Jiai Yan et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Identification and synthesis of multifunctional peptides from wheat germ hydrolysate fractions obtained by proteinase K digestion

Zohreh Karami et al.

JOURNAL OF FOOD BIOCHEMISTRY (2019)

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Article Food Science & Technology

Impact of selected process parameters on solubility and heat stability of pea protein isolate

Dimuthu Bogahawaththa et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2019)

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Article Food Science & Technology

Antioxidant and anti-inflammatory polyphenols and peptides of common bean (Phaseolus vulga L.) milk and yogurt in Caco-2 and HT-29 cell models

Yuhuan Chen et al.

JOURNAL OF FUNCTIONAL FOODS (2019)

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Review Food Science & Technology

Recent progress in the utilization of pea protein as an emulsifier for food applications

Travis G. Burger et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2019)

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Review Food Science & Technology

Bioavailability of bioactive peptides derived from food proteins across the intestinal epithelial membrane: A review

Qingbiao Xu et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2019)

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Article Nutrition & Dietetics

Antidiabetic Effects of a Short Peptide of Potato Protein Hydrolysate in STZ-Induced Diabetic Mice

Shibu Marthandam Asokan et al.

NUTRIENTS (2019)

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Article Food Science & Technology

Marine collagen peptide as a fortificant for biscuit: Effects on biscuit attributes

Anuj Kumar et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2019)

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Review Food Science & Technology

Regulatory requirements of bioactive peptides (protein hydrolysates) from food proteins

Meram Chalamaiah et al.

JOURNAL OF FUNCTIONAL FOODS (2019)

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Article Chemistry, Applied

Complexation between flaxseed protein isolate and phenolic compounds: Effects on interfacial, emulsifying and antioxidant properties of emulsions

Loc B. Pham et al.

FOOD HYDROCOLLOIDS (2019)

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Article Biochemistry & Molecular Biology

Isolation and functional characterization of an antifungal hydrophilic peptide, Skh-AMP1, derived from Satureja khuzistanica leaves

Soghra Khani et al.

PHYTOCHEMISTRY (2019)

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Article Chemistry, Applied

Gelling and emulsifying properties of soy protein hydrolysates in the presence of a neutral polysaccharide

Jose A. Lopes-da-Silva et al.

FOOD CHEMISTRY (2019)

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Article Food Science & Technology

Bioactive Phaseolus lunatus peptides release from maltodextrin/gum arabic microcapsules obtained by spray drying after simulated gastrointestinal digestion

Raul E. Cian et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2019)

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Article Agriculture, Multidisciplinary

Transport, Bioavailability, Safety, and Calmodulin-Dependent-Phosphodiesterase-Inhibitory Properties of Flaxseed-Derived Bioactive Peptides

Ifeanyi D. Nwachukwu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Review Nutrition & Dietetics

Peptides and Peptidomimetics as Potential Antiobesity Agents: Overview of Current Status

Maushmi S. Kumar

FRONTIERS IN NUTRITION (2019)

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Review Food Science & Technology

Functional food products in Japan: A review

Shun Iwatani et al.

FOOD SCIENCE AND HUMAN WELLNESS (2019)

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Review Chemistry, Physical

Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review

David Julian McClements

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2018)

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Article Pharmacology & Pharmacy

PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention

Atanaska I. Kostadinova et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

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Review Chemistry, Applied

Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review

Meram Chalamaiah et al.

FOOD CHEMISTRY (2018)

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Article Agriculture, Multidisciplinary

Identification of Bioactive Peptides with α-Amylase Inhibitory Potential from Enzymatic Protein Hydrolysates of Red Seaweed (Porphyra spp)

Habtamu Admassu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Allergy

Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation

Matthew T. Walker et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Allergy

Treatment for food allergy

A. Wesley Burks et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Nursing

Hypertension among adults living in Haiti: An integrative review

Diana-Lyn Baptiste et al.

JOURNAL OF CLINICAL NURSING (2018)

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Review Agriculture, Multidisciplinary

Review on plant protein-polysaccharide complex coacervation, and the functionality and applicability of formed complexes

Sumudu N. Warnakulasuriya et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2018)

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Article Biochemistry & Molecular Biology

A novel ACE inhibitory peptide derived from alkaline hydrolysis of ostrich (Struthio camelus) egg white ovalbumin

Siriporn Khueychai et al.

PROCESS BIOCHEMISTRY (2018)

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Article Food Science & Technology

Purification and identification of anti-obesity peptides derived from Spirulina platensis

Xiaodan Fan et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

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Article Food Science & Technology

Behavior of three hypocholesterolemic peptides from soy protein in an intestinal model based on differentiated Caco-2 cell

Gilda Aiello et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

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Article Biochemistry & Molecular Biology

Spirulina maxima peptides suppress mast cell degranulation via inactivating Akt and MAPKs phosphorylation in RBL-2H3 cells

Thanh Sang Vo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Nutrition & Dietetics

Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities

Subhadeep Chakrabarti et al.

NUTRIENTS (2018)

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Article Food Science & Technology

Mung bean proteins and peptides: nutritional, functional and bioactive properties

Zhu Yi-Shen et al.

FOOD & NUTRITION RESEARCH (2018)

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Review Food Science & Technology

Immunomodulating peptides for food allergy prevention and treatment

Daniel Lozano-Ojalvo et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2018)

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Review Food Science & Technology

Dietary bioactive peptides: Human studies

Dominique Bougle et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

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Review Food Science & Technology

Effect of processing on nutritive values of milk protein

Sanket G. Borad et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

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Review Food Science & Technology

Bioactive protein hydrolysates in the functional food ingredient industry: Overcoming current challenges

Tomas Lafarga et al.

FOOD REVIEWS INTERNATIONAL (2017)

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Article Food Science & Technology

Peanut digestome: Identification of digestion resistant IgE binding peptides

Luigia Di Stasio et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

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Article Chemistry, Applied

Development of a workflow for screening and identification of α-amylase inhibitory peptides from food source using an integrated Bioinformatics-phage display approach: Case study - Cumin seed

Hwee-Leng Siow et al.

FOOD CHEMISTRY (2017)

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Article Food Science & Technology

Quantification of egg ovalbumin hydrolysate-derived anti-hypertensive peptides in an in vitro model combining luminal digestion with intestinal Caco-2 cell transport

Charlotte Grootaert et al.

FOOD RESEARCH INTERNATIONAL (2017)

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Article Biochemical Research Methods

A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods

Sophie Bromilow et al.

JOURNAL OF PROTEOMICS (2017)

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Editorial Material Biotechnology & Applied Microbiology

Predictive Protein Toxicity and Its Use in Risk Assessment

Niccolo Franceschi et al.

TRENDS IN BIOTECHNOLOGY (2017)

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Article Food Science & Technology

The investigation of α-amylase inhibitory activity of selected Pinto bean peptides via preclinical study using AR42J cell

Ying-Yuan Ngoh et al.

JOURNAL OF FUNCTIONAL FOODS (2017)

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Article Food Science & Technology

Release of dipeptidyl peptidase IV, α-amylase and α-glucosidase inhibitory peptides from quinoa (Chenopodium quinoa Willd.) during in vitro simulated gastrointestinal digestion

Ruben Vilcacundo et al.

JOURNAL OF FUNCTIONAL FOODS (2017)

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Article Biotechnology & Applied Microbiology

Optimization of the Extraction and Stability of Antioxidative Peptides from Mackerel (Pneumatophorus japonicus) Protein

Xueqin Wang et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Article Chemistry, Multidisciplinary

Improved In Vivo Efficacy of Anti-Hypertensive Biopeptides Encapsulated in Chitosan Nanoparticles Fabricated by Ionotropic Gelation on Spontaneously Hypertensive Rats

Shehu Muhammad Auwal et al.

NANOMATERIALS (2017)

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Article Nutrition & Dietetics

Effects of NWT-03, an egg-protein hydrolysate, on blood pressure in normotensive, high-normotensive and mild-hypertensive men and women: a dose-finding study

Jogchum Plat et al.

BRITISH JOURNAL OF NUTRITION (2017)

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Review Food Science & Technology

Food Allergens: Is There A Correlation between Stability to Digestion and Allergenicity?

Katrine Lindholm Bogh et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2016)

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Review Pharmacology & Pharmacy

Mucoadhesive vs. mucopenetrating particulate drug delivery

Kesinee Netsomboon et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

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Article Food Science & Technology

Anti-obesity effects of seaweeds of Jeju Island on the differentiation of 3T3-L1 preadipocytes and obese mice fed a high-fat diet

Min-Cheol Kang et al.

FOOD AND CHEMICAL TOXICOLOGY (2016)

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Review Chemistry, Applied

Functional properties of peptides: From single peptide solutions to a mixture of peptides in food products

Lelia Lacou et al.

FOOD HYDROCOLLOIDS (2016)

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Article Food Science & Technology

Identification of casein peptides in plasma of subjects after a cheese-enriched diet

Simonetta Caira et al.

FOOD RESEARCH INTERNATIONAL (2016)

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Article Cardiac & Cardiovascular Systems

Comprehensive assessment of lipoprotein subfraction profiles according to glucose metabolism status, and association with insulin resistance in subjects with early-stage impaired glucose metabolism

Jie-Eun Lee et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

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Review Chemistry, Medicinal

Marine Algae as a Potential Source for Anti-Obesity Agents

Chu Wan-Loy et al.

MARINE DRUGS (2016)

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Review Food Science & Technology

AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity

Richard E. Goodman et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2016)

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Review Biochemistry & Molecular Biology

Fish Hydrolysates: A Regulatory Perspective of Bioactive Peptides

Bert Gevaert et al.

PROTEIN AND PEPTIDE LETTERS (2016)

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Review Biology

Milk derived bioactive peptides and their impact on human health - A review

D. P. Mohanty et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2016)

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Article Multidisciplinary Sciences

A Web Server and Mobile App for Computing Hemolytic Potency of Peptides

Kumardeep Chaudhary et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Conformational stability of digestion-resistant peptides of peanut conglutins reveals the molecular basis of their allergenicity

Danijela Apostolovic et al.

SCIENTIFIC REPORTS (2016)

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Article Food Science & Technology

General scientific guidance for stakeholders on health claim applications

Jean Louis Bresson et al.

EFSA JOURNAL (2016)

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Article Food Science & Technology

Hard-to-cook bean (Phaseolus vulgaris L.) proteins hydrolyzed by alcalase and bromelain produced bioactive peptide fractions that inhibit targets of type-2 diabetes and oxidative stress

Miguel E. Oseguera-Toledo et al.

FOOD RESEARCH INTERNATIONAL (2015)

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Review Biochemistry & Molecular Biology

The Role of Food Peptides in Lipid Metabolism during Dyslipidemia and Associated Health Conditions

Chibuike C. Udenigwe et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Chemistry, Medicinal

Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats

Lanlan Huang et al.

MARINE DRUGS (2015)

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Review Biochemistry & Molecular Biology

Toxic proteins in plants

Liuyi Dang et al.

PHYTOCHEMISTRY (2015)

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Article Food Science & Technology

Towards the design of hypolipidaemic peptides: Deoxycholate binding affinity of hydrophobic peptide aggregates of casein plastein

Aishwarya Mohan et al.

JOURNAL OF FUNCTIONAL FOODS (2015)

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Article Mathematical & Computational Biology

ProPepper: a curated database for identification and analysis of peptide and immune-responsive epitope composition of cereal grain protein families

Angela Juhasz et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2015)

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Article Pharmacology & Pharmacy

Novel Delivery Systems for Anti-Allergic Agents: Allergic Disease and Innovative Treatments

Carla M. Lopes et al.

CURRENT DRUG DELIVERY (2015)

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Article Food Science & Technology

Alternative Treatments for Weight Loss: Safety/Risks and Effectiveness of Anti-Obesity Medicinal Plants

Mahnaz Kazemipoor et al.

INTERNATIONAL JOURNAL OF FOOD PROPERTIES (2015)

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Article Nutrition & Dietetics

Infant formula and infant nutrition: bioactive proteins of human milk and implications for composition of infant formulas

Bo Loennerdal

AMERICAN JOURNAL OF CLINICAL NUTRITION (2014)

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Review Allergy

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Scott H. Sicherer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

ANGIOTENSIN I-CONVERTING ENZYME INHIBITORY PEPTIDES FROM SNAKEHEAD FISH SARCOPLASMIC PROTEIN HYDROLYSATE

Masomeh Ghassem et al.

JOURNAL OF FOOD BIOCHEMISTRY (2014)

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Review Nutrition & Dietetics

Are intact peptides absorbed from the healthy gut in the adult human?

Warren M. Miner-Williams et al.

NUTRITION RESEARCH REVIEWS (2014)

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Review Biochemistry & Molecular Biology

Functional significance of bioactive peptides derived from soybean

Brij Pal Singh et al.

PEPTIDES (2014)

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Article Pharmacology & Pharmacy

Recent Advances in Immunotherapy for Allergic Diseases

David El-Qutob et al.

RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY (2014)

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Review Pharmacology & Pharmacy

Approaches for enhancing oral bioavailability of peptides and proteins

Jwala Renukuntla et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Agriculture, Multidisciplinary

Comparative study on chemical compositions and properties of protein isolates from mung bean, black bean and bambara groundnut

Tanaji G. Kudre et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2013)

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Article Multidisciplinary Sciences

Multi-Functional Roles of Chitosan as a Potential Protective Agent against Obesity

Ann M. Walsh et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

In Silico Approach for Predicting Toxicity of Peptides and Proteins

Sudheer Gupta et al.

PLOS ONE (2013)

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Review Chemistry, Analytical

Protein digestomics: Integrated platforms to study food-protein digestion and derived functional and active peptides

Gianluca Picariello et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2013)

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Article Allergy

Advances in Diagnosing Peanut Allergy

Scott H. Sicherer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2013)

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Article Food Science & Technology

Acute effect of whey peptides upon blood pressure of hypertensive rats, and relationship with their angiotensin-converting enzyme inhibitory activity

Tania Tavares et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2012)

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Article Medicine, Research & Experimental

Essential hypertension - Is erroneous receptor output to blame?

Marcin Ufnal

MEDICAL HYPOTHESES (2012)

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Article Biochemistry & Molecular Biology

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

Quentin Kaas et al.

NUCLEIC ACIDS RESEARCH (2012)

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Article Biochemistry & Molecular Biology

DBETH: A Database of Bacterial Exotoxins for Human

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NUCLEIC ACIDS RESEARCH (2012)

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Review Gastroenterology & Hepatology

Acute Liver Failure Caused by Amanita phalloides Poisoning

Luca Santi et al.

INTERNATIONAL JOURNAL OF HEPATOLOGY (2012)

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Review Allergy

Cow's milk allergy as a global challenge

Cansin Sackesen et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2011)

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Review Food Science & Technology

Bioavailability of Bioactive Peptides

Maira Segura-Campos et al.

FOOD REVIEWS INTERNATIONAL (2011)

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Article Agriculture, Multidisciplinary

Identification of Isopeptide Bonds in Heat-Treated Wheat Gluten Peptides

Ine Rombouts et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

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Editorial Material Cell Biology

Adipogenesis at a glance

Christopher E. Lowe et al.

JOURNAL OF CELL SCIENCE (2011)

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Review Food Science & Technology

Role and classification of cholesterol-lowering functional foods

Zhen-Yu Chen et al.

JOURNAL OF FUNCTIONAL FOODS (2011)

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Review Nutrition & Dietetics

Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract

Alireza Jahan-Mihan et al.

NUTRIENTS (2011)

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Article Food Science & Technology

Acute and repeated dose (4 weeks) oral toxicity studies of two antihypertensive peptides, RYLGY and AYFYPEL, that correspond to fragments (90-94) and (143-149) from αs1-casein

A. Anadon et al.

FOOD AND CHEMICAL TOXICOLOGY (2010)

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Article Biochemical Research Methods

Peptides surviving the simulated gastrointestinal digestion of milk proteins: Biological and toxicological implications

Gianluca Picariello et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2010)

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Article Nutrition & Dietetics

Current In Vitro Testing of Bioactive Peptides Is Not Valuable

Martin Foltz et al.

JOURNAL OF NUTRITION (2010)

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Review Chemistry, Medicinal

Angiotensin-I-Converting Enzyme (ACE) Inhibitors from Marine Resources: Prospects in the Pharmaceutical Industry

Isuru Wijesekara et al.

MARINE DRUGS (2010)

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Article Pharmacology & Pharmacy

ATDB 2.0: A database integrated toxin-ion channel interaction data

Quanze He et al.

TOXICON (2010)

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Article Food Science & Technology

Scientific Opinion on the substantiation of health claims related to bonito protein peptide and maintenance of normal blood pressure (ID 1716) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)

Carlo Agostoni et al.

EFSA JOURNAL (2010)

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Article Oncology

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway

Bo Liu et al.

CANCER LETTERS (2009)

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Review Nutrition & Dietetics

Safety of protein hydrolysates, fractions thereof and bioactive peptides in human nutrition

G. Schaafsma

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2009)

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Article Food Science & Technology

Safety evaluation of an IPP tripeptide-containing milk protein hydrolysate

A. Y. Ponstein-Simarro Doorten et al.

FOOD AND CHEMICAL TOXICOLOGY (2009)

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Article Biochemistry & Molecular Biology

Crystal structure of Ara h 3, a major allergen in peanut

Tengchuan Jin et al.

MOLECULAR IMMUNOLOGY (2009)

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Article Biochemistry & Molecular Biology

ClanTox: a classifier of short animal toxins

Guy Naamati et al.

NUCLEIC ACIDS RESEARCH (2009)

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Article Pharmacology & Pharmacy

Targeted drug delivery: Binding and uptake of plant lectins using human 5637 bladder cancer cells

Verena E. Plattner et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2008)

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Article Food Science & Technology

In vitro and in vivo safety studies of a proprietary whey extract

Anthony R. Dyer et al.

FOOD AND CHEMICAL TOXICOLOGY (2008)

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Article Chemistry, Applied

Purification and identification of a ACE inhibitory peptide from oyster proteins hydrolysate and the anti hypertensive effect of hydrolysate in spontaneously hypertensive rats

Jiapei Wang et al.

FOOD CHEMISTRY (2008)

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Article Medicine, Research & Experimental

Targeted Disruption of Peptide Transporter Pept1 Gene in Mice Significantly Reduces Dipeptide Absorption in Intestine

Yongun Hu et al.

MOLECULAR PHARMACEUTICS (2008)

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Article Agriculture, Multidisciplinary

Conversion of phenylalanine into styrene by 2,4-decadienal in model systems

Francisco J. Hidalgo et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)

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Review Pharmacology & Pharmacy

Cytotoxic and allergenic potential of bioactive proteins and peptides

Rainer Hartmann et al.

CURRENT PHARMACEUTICAL DESIGN (2007)

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Article Agriculture, Multidisciplinary

Characterization of reaction products formed in a model reaction between pentanal and lysine-containing oligopeptides

Trine K. Dalsgaard et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2006)

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Article Pharmacology & Pharmacy

Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): IV. Assessment of the repeated-dose toxicological potential of synthesized L-valyl-L-prolyl-L-proline in male and female rats and dogs

Y Nakamura et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2005)

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Article Pharmacology & Pharmacy

Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): V. A 13-week toxicity study of tripeptides-containing casein hydrolysate in male and female rats

S Mizuno et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2005)

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Article Pharmacology & Pharmacy

Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): III. Single- and/or repeated-dose toxicity of tripeptides-containing Lactobacillus helveticus-fermented milk powder and casein hydrolysate in rats

M Maeno et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2005)

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Article Endocrinology & Metabolism

Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women

V van Harmelen et al.

INTERNATIONAL JOURNAL OF OBESITY (2003)

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Article Agriculture, Multidisciplinary

Microencapsulation and modification of synthetic peptides of food proteins reduces the blood pressure of spontaneously hypertensive rats

TL Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers

M Satake et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2002)

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Article Nutrition & Dietetics

Newly established regulation in Japan: foods with health claims

T Shimizu

ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION (2002)

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Article Agriculture, Multidisciplinary

Heat-induced destabilization of oil-in-water emulsions formed from hydrolyzed whey protein

SR Euston et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)

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