期刊
COMPOSITES PART B-ENGINEERING
卷 230, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.compositesb.2021.109524
关键词
Decellularized; Extracellular matrix; Macrophage; T helper cell; Immunomodulation
资金
- National Natural Science Foundation of China [81930069, 82002291]
- Key Projects of Scientific Research and Innovation, Shanghai Municipal Education Commission [201901070002E00043]
- National Key R&D program of China [2020YFC2004906]
- Project of Shandong medical and health science development [202003101384]
Decellularized biomaterials have shown great potential in regenerative medicine, with good biocompatibility and interaction with the immune system being important factors to consider. Understanding the immunogenicity and immunomodulatory effects of decellularized scaffolds on innate and adaptive immune systems is crucial for their clinical translation. Host responses mediated by decellularized biomaterials can provide insights for further development and application in vivo.
A promising paradigm to regenerative medicine involves the application of biomaterials, which makes a spurt of progress in the past 20 years. Of various biomaterials, decellularized biomaterials possess good biocompatibility and great potential for clinical translation. The role of decellularized biomaterials in tissue repair and regeneration is not just the structure and delivering bioactive matters, what's even important, the interaction between biomaterials and the internal environment, especially the scaffold-immune system interactions, which is the initial response to in vivo implantation. Consequently, we have reviewed the immunogenicity of decellularized scaffolds derived from various tissues and organs, and immunomodulatory effects of decellularized scaffolds in the view of innate and adaptive immune systems. Finally, we discuss the influence factors of host responses mediated by decellularized biomaterials. Decellularized scaffold-immune interactions can provide important mechanistic insight into the development of decellularized materials in vivo, penetrating into the knowledge is the necessary precondition for the clinical translation.
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