期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 632, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2021.127740
关键词
nitric oxide; camptothecin; nanoparticles; co-delivery; drug delivery systems; hybrid; PLGA; silica; combination therapy
资金
- Ministry of Science and Technology, Taiwan [MOST 105-2320-B-016-006-MY3, MOST 108-2320-B-010-037MY3]
- Higher Education Sprout Project of the National Yang Ming Chiao Tung University
- Ministry of Education (MOE), Taiwan
The study successfully demonstrates the feasibility of co-delivering CPT and NO using hybrid colloidal particle carriers, leading to augmented anticancer activities. Three formulations with different ratios of CPT and NO were prepared, showing increased cytotoxicity against various cancer cell lines.
Camptothecin (CPT) is a highly potent anticancer agent with low water solubility and high toxicity. Nitric oxide (NO) is a gaseous free-radical molecule with potential to enhance anticancer chemotherapy. In this study, we designed and fabricated hybrid colloidal particle carriers for simultaneous delivery of CPT and NO, aiming to produce augmented anticancer activities. The drug carrier contains two separate domains, where CPT is physically loaded in the PLGA particle and NO is chemically conjugated to the organosilica scaffold via S-nitrosothiol linkage. The fabrication involves preparation of CPT-loaded PLGA particles and deposition of S-nitroso-orga-nosilica, leading to the formation of anisotropic, Janus-like colloidal particles. We prepared and characterized 3 formulations with various entrapment amounts of CPT and NO (CPT:NO molar ratio = 1:4, 1:15, and 1:200). The release study demonstrates successful co-delivery of CPT and NO. Moreover, the formulations show increased cytotoxicity with increasing NO loading against various cancer cell lines. In conclusion, our study demonstrates the feasibility of co-delivering CPT and NO using organic-inorganic composite particle carriers. The hybrid nanocarriers increase the versatility of colloidal anticancer drug delivery.
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