期刊
CNS NEUROSCIENCE & THERAPEUTICS
卷 28, 期 1, 页码 158-171出版社
WILEY
DOI: 10.1111/cns.13749
关键词
GDF15; glioma; biomarker; Immune; prognosis
资金
- Natural Science Foundation of Guangdong Province [2020A1515010186]
- National Natural Science Foundation of China [81972970, 82172671]
This study found that GDF15 is upregulated in various malignant phenotypes of glioma and is associated with malignant progression and NF-kappa B pathway. GDF15 is closely correlated to inflammatory response, infiltrating immune cells, and immune checkpoint molecules, especially in lower grade glioma (LGG). High expression level of GDF15 predicted poor survival in LGG, while the effect on glioblastoma (GBM) was not significant.
Aims Growth differentiation factor 15 (GDF15) is involved in lots of crucial inflammatory and immune response. The clinical and immune features for GDF15 in glioma have not been specifically investigated so far. Methods Gene expression profiles obtained from public glioma datasets were used to explore the biological function of GDF15 and its impact on immune microenvironment. Interference with GDF15 in several glioma cell lines to verify its functions in vitro. Survival data were used for the survival analysis and establishment of a nomogram predictive model. Results GDF15 was up-regulated in various malignant phenotypes of glioma. Function analysis and in vitro experiments revealed that GDF15 was associated with malignant progression and NF-kappa B pathway. GDF15 was closely correlated to inflammatory response, infiltrating immune cells, and immune checkpoint molecules, especially in lower grade glioma (LGG). High expression level of GDF15 predicted poor survival in LGG, while the effect on glioblastoma (GBM) was not significant. A nomogram predictive model combining GDF15 and other prognostic factors was constructed and showed ideal predictive performance. Conclusions GDF15 could serve as an interesting prognostic biomarker for LGG. Regulating the expression of GDF15 may help solve the dilemma of immunotherapy in glioma.
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