期刊
CLINICAL TRANSPLANTATION
卷 36, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/ctr.14591
关键词
heart (allograft) function; dysfunction; heart disease; organ perfusion and preservation; patient survival
资金
- National Institutes of Health [T32HL116273]
This study evaluated the long-term outcomes of heart transplants preserved using the Organ Care System (OCS). The results showed that the survival rate and incidence of graft-related complications in patients with OCS-preserved grafts were comparable to those with grafts preserved using standard cold storage.
Introduction The Organ Care System (OCS) is an ex vivo perfusion platform for donor heart preservation. Short/mid-term post-transplant outcomes after its use are comparable to standard cold storage (CS). We evaluated long-term outcomes following its use. Methods Between 2011 and 2013, 38 patients from a single center were randomized as a part of the PROCEED II trial to receive allografts preserved with CS (n = 19) or OCS (n = 19). Endpoints included 8-year survival, survival free from graft-related deaths, freedom from cardiac allograft vasculopathy (CAV), non-fatal major adverse cardiac events (NF-MACE), and rejections. Results Eight-year survival was 57.9% in the OCS group and 73.7% in the CS group (p = .24). Freedom from CAV was 89.5% in the OCS group and 67.8% in the CS group (p = .13). Freedom from NF-MACE was 89.5% in the OCS group and 67.5% in the CS group (p = .14). Eight-year survival free from graft-related death was equivalent between the two groups (84.2% vs. 84.2%, p = .93). No differences in rejection episodes were observed (all p > .5). Conclusions In select patients receiving OCS preserved allografts, late post-transplant survival trended lower than those transplanted with an allograft preserved with CS. This is based on a small single-center series, and larger numbers are needed to confirm these findings.
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