期刊
CLINICAL TRANSPLANTATION
卷 36, 期 1, 页码 -出版社
WILEY
DOI: 10.1111/ctr.14495
关键词
BNT162b2 vaccine; COVID-19; graft rejection; HLA-DSA; kidney transplantation; solid organ transplant patients
Solid organ transplant patients are at higher risk for poor COVID-19-related outcomes and have been prioritized for vaccination. A study in Italy assessed the safety and efficacy of the BNT162b2 mRNA vaccine in 82 kidney transplant patients, finding a 52.4% seroprevalence after 43 days post-vaccination with no impact on rejection or graft function. Age over 60 and use of anti-metabolites were associated with lack of seroconversion following vaccination. Further large studies are needed to determine the best vaccination strategy for transplanted patients.
Solid organ transplant patients are at a higher risk for poor CoronaVirus Disease-2019 (COVID-19)-related outcomes and have been included as a priority group in the vaccination strategy worldwide. We assessed the safety and efficacy of a two-dose vaccination cycle with mRNA-based COVID-19 vaccine (BNT162b2) among 82 kidney transplant outpatients followed in our center in Rome, Italy. After a median of 43 post-vaccine days, a SARS-CoV-2 anti-Spike seroprevalence of 52.4% (n = 43/82) was observed. No impact of the vaccination on antibody-mediated rejection or graft function was observed, and no significant safety concerns were reported. Moreover, no de novo HLA-donor-specific antibodies (DSA) were detected during the follow-up period. Only one patient with pre-vaccination HLA-DSA did not experience an increased intensity of the existing HLA-DSA. During the follow-up, only one infection (mild COVID-19) was observed in a patient after receiving the first vaccine dose. According to the multivariable logistic regression analysis, lack of seroconversion after two-dose vaccination independently associated with patient age >= 60 years (OR = 4.50; P = .02) and use of anti-metabolite as an immunosuppressant drug (OR = 5.26; P = .004). Among younger patients not taking anti-metabolites, the seroconversion rate was high (92.9%). Further larger studies are needed to assess the best COVID-19 vaccination strategy in transplanted patients.
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