期刊
CLINICAL ORAL INVESTIGATIONS
卷 26, 期 5, 页码 3949-3964出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00784-021-04362-0
关键词
Benign mucous membrane pemphigoid; Oral lichen planus; Pemphigus vulgaris; Photobiomodulation therapy
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [408884/2018-5]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
Through comprehensive electronic searches and meta-analysis, the study found that photobiomodulation (PBM) has significant therapeutic effects on gingival lesions resulting from autoimmune diseases. It can significantly reduce pain and improve clinical scores, with no significant differences compared to topical corticosteroid (CS) treatment.
Objectives To evaluate the effects of photobiomodulation (PBM) in gingival lesions resulting from autoimmune diseases; to compare PBM and topical corticosteroid (CS) treatment; and to assess PBM outcome over time of follow-up. Materials and methods A comprehensive electronic search was performed in four electronic databases. Treatment effects were measured through visual analog scale of pain (VAS) and clinical evolution of lesion (Thongprasom scale for oral lichen planus (OLP)). Meta-analysis was performed to compare PBM with topical corticosteroid treatment and to evaluate PBM effect over time of follow-up. Results Seventeen studies were included in this review, of which six were used for the meta-analysis. Meta-analysis results showed no significant differences between PBM and topical CS in pain reduction at baseline (MD = 0.20, 95% CI= - 0.92, 1.32, p = 0.72) and 60-day follow-up (MD = 0.63, 95% CI= - 3.93, 5.19, p = 0.79); however, VAS showed significant pain reduction when compared before and after PBM at 30-day (MD= - 3.52, 95% CI= - 5.40, -1.64, p= 0.0002) and 60-day (MD = - 5.04, 95% CI = - 5.86, - 4.22, p < 0.00001) follow-up. Thongprasom clinical scale for OLP also showed significant improvement at 30-day follow-up (MD = - 2.50, 95% CI = - 2.92, - 2.08, p < 0.00001) after PBM. Conclusion PBM led to significant reduction of pain and clinical scores of the lesions, not having shown significant differences when compared to topical CS.
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