期刊
CLINICAL NEUROPHYSIOLOGY
卷 132, 期 10, 页码 2540-2550出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2021.06.036
关键词
Functional Connectivity Network; Construction; fMRI; Alzheimer's Disease; Mild Cognitive Impairment; Node2vec
资金
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd
- Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
This study introduces a novel method based on resting-state functional connectivity for accurate classification of individuals at different stages of dementia, achieving promising results with high accuracy rates.
Objective: Resting-state functional connectivity reveals a promising way for the early detection of dementia. This study proposes a novel method to accurately classify Healthy Controls, Early Mild Cognitive Impairment, Late Mild Cognitive Impairment, and Alzheimer's Disease individuals. Methods: A novel mapping function based on the B distribution has been developed to map correlation matrices to robust functional connectivity. The node2vec algorithm is applied to the functional connectivity to produce node embeddings. The concatenation of these embedding has been used to derive the patients' feature vectors for further feeding into the Support Vector Machine and Logistic Regression classifiers. Results: The experimental results indicate promising results in the complex four-class classification problem with an accuracy rate of 97.73% and a quadratic kappa score of 96.86% for the Support Vector Machine. These values are 97.32% and 96.74% for Logistic Regression. Conclusion: This study presents an accurate automated method for dementia classification. Default Mode Network and Dorsal Attention Network have been found to demonstrate a significant role in the classification method. Significance: A new mapping function is proposed in this study, the mapping function improves accuracy by 10-11% in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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