Understanding the genetics of intracranial aneurysms: A primer

The genetics of intracranial aneurysms is complex. Much work has been done looking at the extracellular matrix surrounding cerebral vasculature as well as the role of matrix metalloproteinases. This comprehensive review summarizes what is known to date about the important genetic components that predispose to aneurysm formation and critically discusses the published findings. We discuss promising pre-clinical models of aneurysm formation and subarachnoid hemorrhage, and highlight avenues for future discovery, while considering limitations in the research to date. This review will further serve as a comprehensive reference guide to understand the genetic underpinnings for aneurysm pathophysiology and act as a primer for further investigation.

Automated summary

This article reviews the complex genetics of intracranial aneurysms and critically discusses the published findings. It explores promising pre-clinical models and future avenues for research, while considering limitations in current studies. This review is of great importance in understanding the genetic underpinnings of aneurysm pathophysiology and as a primer for further investigation.