4.3 Article

Cerebrospinal fluid analysis is associated with enhancement on MRI in bacterial and tuberculous meningitis: A retrospective observational study

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CLINICAL NEUROLOGY AND NEUROSURGERY
卷 212, 期 -, 页码 -

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ELSEVIER
DOI: 10.1016/j.clineuro.2021.107036

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Meningitis; Bacterial meningitis; Tuberculous meningitis; Cerebrospinal fluid; Contrast-enhanced Magnetic Resonance; Imaging

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This study investigates the association between CSF parameters and enhancement on contrast-enhanced MRI in patients with bacterial meningitis (BM) or tuberculous meningitis (TM). The findings suggest that CSF analysis is important in assessing the need for contrast-enhanced MRI, which may be useful in diagnosis, distinction, and prognosis estimation.
Objective: Along with cerebrospinal fluid (CSF) analysis, enhancement on contrast-enhanced MRI is useful to diagnose meningitis. However, the conditions for its appearance have not been clarified. This study aimed to investigate the association between CSF parameters and enhancement on contrast-enhanced head or spinal MRI in patients with bacterial meningitis (BM) or tuberculous meningitis (TM). Methods: A total of 12 patients with BM and 23 patients with TM who underwent both CSF analysis and contrast enhanced MRI were included. The correlation between CSF analysis and MRI findings has been examined using receiver operating characteristic (ROC) analysis. Results: Contrast enhancement was found in 7 and 10 patients with BM and TM, respectively. Both CSF analysis and MRI were useful to distinct between BM and TM, and the enhancement implied the severity of them. In patients with BM, higher CSF protein and lower CSF glucose were associated with enhancement on MRI, while not only CSF protein and glucose but also leukocyte and lymphocyte counts were associated with it in TM. CSF adenosine deaminase (ADA) did not show discriminant ability of the MRI findings. Conclusions: CSF analysis is associated with enhancement on contrast-enhanced MRI both in BM and TM. Our findings indicate the importance of CSF analysis in assessing the need to perform contrast-enhanced MRI, which may be useful in diagnosis, distinction, and estimation of prognosis in those patients.

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