期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 28, 期 3, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2021.12.001
关键词
Mink; SARS-CoV-2; Spill-over; Transmission; Zoonoses
资金
- 2018-2019 BiodivERsA joint call for research proposals, under the BiodivERsA3 ERA-Net COFUND program
- ANR (France)
- DFG (Germany)
- EPA (Ireland)
- FWO (Belgium)
- NCN (Poland)
- VEO-European Union Horizon 2020 [874735]
- Jane and Aatos Erkko Foundation
- Polish Ministry of Science and Higher Education
This study analyzed the possible zoonotic spill-over of SARS-CoV-2 and reported the transmission of mink-adapted SARS-CoV-2 from farmed mink to humans for at least 3 months.
Objectives: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. Methods: Next-generation sequencing and a bioinformatic approach were applied to analyse the data. Results: In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others. Conclusions: Zoonotic spill-over of SARS-CoV-2 can occur from mink to human. (C) 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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