Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas

Recurrent glomerular disease after kidney transplant remains an important cause of allograft failure. Many of the different entities post-transplant still suffer from incomplete knowledge on pathophysiology, and therefore lack targeted and effective therapies. In this review, we focus on specific clinical dilemmas encountered by physicians in managing recurrent glomerular disease by highlighting new insights into the understanding and treatment of post-transplant focal segmental glomerulosclerosis, membranous nephropathy, atypical hemolytic uremic syndrome, C3 glomerulopathy, amyloid light-chain (AL) amyloidosis, and IgA nephropathy.

Automated summary

Recurrent glomerular disease after kidney transplant is a significant cause of allograft failure, with incomplete knowledge on pathophysiology leading to a lack of targeted and effective therapies. In this review, specific clinical dilemmas in managing recurrent glomerular disease are highlighted, focusing on new insights into understanding and treating post-transplant diseases such as focal segmental glomerulosclerosis, membranous nephropathy, atypical hemolytic uremic syndrome, C3 glomerulopathy, amyloid light-chain (AL) amyloidosis, and IgA nephropathy.