期刊
CLINICAL INFECTIOUS DISEASES
卷 75, 期 6, 页码 1081-1084出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciac078
关键词
carbapenem resistance; cefiderocol; eradication; metallo-beta-lactamase; NDM
资金
- Shionogi & Co, Ltd, Osaka, Japan
The CREDIBLE-CR and APEKS-NP studies showed that cefiderocol treatment is effective against gram-negative bacteria producing metallo-B-lactamases, with favorable rates of clinical cure, microbiological eradication, and all-cause mortality compared to other treatment options.
In the CREDIBLE-CR and APEKS-NP studies, cefiderocol treatment was effective against gram-negative bacteria producing metallo-B-lactamases; rates of clinical cure (70.8% [17/24]), microbiological eradication (58.3% [14/24]), and day 28 all-cause mortality (12.5% [3/24]) compared favorably with comparators of best-available therapy and high-dose meropenem (40.0% [4/10], 30.0% [3/10], and 50.0% [5/10], respectively).
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