Role of NRF2 and Sirtuin activators in COVID-19

COVID-19 is a pandemic requiring immediate solution for treatment because of its complex pathophysiology. Exploration of novel targets and thus treatment will be life savers which is the need of the hour. 2 host factorsTMPRSS2 and ACE2 are responsible for the way the virus will enter and replicate in the host. Also NRF2 is an important protein responsible for its anti-inflammatory role by multiple mechanisms of action like inhibition of NF-kB, suppression of pro-inflammatory genes, etc. NRF2 is deacetylated by Sirtuins and therefore both have a direct association. Absence of SIRT indicates inhibition of NRF2 expression and thus no anti-oxidative and antiinflammatory protection for the cell. Therefore, we propose that NRF2 activators and/or SIRT activators can be evaluated to check their efficacy in ameliorating the symptoms of COVID-19.

Automated summary

COVID-19 is a pandemic that requires immediate treatment due to its complex pathophysiology. Novel targets and regulators are crucial for saving lives. The virus enters the host through TMPRSS2 and ACE2, while NRF2 plays a key role in anti-inflammatory actions.