期刊
CLINICAL IMMUNOLOGY
卷 234, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2021.108907
关键词
Lupus; SLE; jSLE; cSLE; Childhood; Juvenile; Pediatric; Therapy; Pathophysiology
类别
This manuscript summarizes the parallels and differences between clinical presentations, pathomechanisms, and treatment options in juvenile-onset SLE versus adult-onset SLE.
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease that can affect any organ system and cause significant damage and organ failure. Disease-onset during childhood (juvenile-onset SLE) is associated with less typical autoantibody patterns, diffuse organ involvement, more damage already at diagnoses, and a higher need of immunomodulating treatment, including corticosteroids, when compared to adult onset SLE. Differences in the molecular pathophysiology within SLE, and over-representation of patients with genetic SLE contribute to differences in clinical presentation and treatment responses between children and adults. This manuscript summarizes currently available literature focusing on parallels and differences between clinical pictures, known pathomechanisms, and available treatment options in juvenile-versus adult-onset SLE.
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