期刊
CLINICAL GENITOURINARY CANCER
卷 20, 期 1, 页码 95-100出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clgc.2021.10.002
关键词
Ureteroscopy; Biopsy; Upper tract urothelial carcinoma; Grade; Stage; Radical nephroureterectomy; Computed tomography urography
This study evaluated the diagnostic ability of ureteroscopic biopsy and computed tomography urography to predict the final pathological tumor stage and grade in patients with upper tract urothelial carcinoma (UTUC). Clinical understaging/undergrading and upstaging to muscle-invasive disease occurred in a high proportion of UTUC patients.
This study evaluated ureteroscopic biopsy and computed tomography urography for their diagnostic ability to accurately predict final pathological tumor stage and grade in patients with upper tract urothelial carcinoma (UTUC). Clinical understaging/undergrading and upstaging to muscle-invasive disease occurred in a high proportion of UTUC patients. These findings should be considered when utilizing preoperative, risk-adapted strategies. Introduction: This study aimed to evaluate the concordance in tumor stage and grade between ureteroscopic (URS) biopsy and radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC). Patients and Methods: Records of 1,214 UTUC patients who had undergone URS biopsy followed by RNU were included. Univariable and multivariable logistic regression analyses were performed to identify factors contributing o the pathological upstaging. Results: The concordance between URS biopsy-based clinical and RNU pathological staging was 34.5%. Clinical understaging occurred in 59.5% patients. Upstaging to muscle-invasive disease occurred in 240 (41.7%) of 575 patients diagnosed with <= cT1 disease. Of those diagnosed with muscle-invasive disease on final pathology, 89.6% had been clinically diagnosed with <= cT1 disease. In the univariabie analyses, computed tomography urography (CTU)-based invasion, ureter location, hydronephrosis, high-grade cytology, high-grade biopsy, sessile architecture, age, and women sex were significantly associated with pathological upstaging (P < .05). In the multivariable analyses, CTU-based invasion and hydronephrosis remained associated with pathological upstaging (P < .05). URS biopsy-based clinical and pathological gradings were concordant in 634 (54.2%) patients. Clinical undergrading occurred in 496 (42.4%) patients. Conclusions: Clinical understaging/undergrading and upstaging to muscle-invasive disease occurred in a high proportion of UTUC patients undergoing RNU. Despite the inherent selection bias, these data underline the challenges of accurate UTUC staging and grading. In daily clinical practice, URS biopsy and CTU offer the most accurate preoperative information albeit with limited predictive value when used alone. These findings should be considered when utilizing preoperative, risk-adapted strategies. (C) 2021 The Author(s). Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据