期刊
CLINICAL ENDOCRINOLOGY
卷 97, 期 3, 页码 303-309出版社
WILEY
DOI: 10.1111/cen.14682
关键词
androgens; central obesity; men's health; metabolic syndrome; race
资金
- UM Wellness Fund
This study investigated factors contributing towards differences in testosterone concentration in multiethnic Malaysian men with multiple comorbidities. The results showed that Malaysian men of Malay origin had lower testosterone concentration compared with Indian and Chinese men. Waist circumference and low high-density lipoprotein levels were also associated with lower testosterone concentrations.
Objective To investigate non-urological patients with multiple comorbidities for factors contributing towards differences in testosterone concentration in multiethnic Malaysian men. Design An observational study. Patients Sexually active men, >= 40 years, with no known urological problems, were recruited at the phlebotomy clinic at our centre. Measurements A brief history along with latest fasting lipid profile and plasma glucose levels were obtained. An Aging Male Symptoms questionnaire was administered; waist circumference (WC) and serum testosterone concentration were measured. Statstical Analysis Analysis of testosterone concentration between Malay, Indian and Chinese men was performed. Statistical tests such as analysis of variance, chi(2) test, univariate and multivariable regression were performed. Any p < .05 was noted as statistically significant. Results Among the 604 participants analysed, mean testosterone concentration was significantly lower in Malays (15.1 +/- 5.9 nmol/L) compared to the Chinese (17.0 +/- 5.9 nmol/L) and Indian (16.1 +/- 6.5 nmol/L) participants. The mean WC was also found to be higher among the Malays (96.1 +/- 10.9 cm) compared to Chinese (92.6 +/- 9.6 cm) and Indians (95.6 +/- 9.9 cm). Testosterone concentration tended to be lower with higher age, but this was not statistically significant (p > .05). In the multivariable analysis only Malay ethnicity, WC >= 90 cm and low high-density lipoprotein (HDL) were associated with lower testosterone concentration. Conclusion In this study, Malaysian men of Malay origin had lower testosterone concentration compared with Indian and Chinese men. WC and low HDL were also associated with lower testosterone concentrations.
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