期刊
CLINICAL COLORECTAL CANCER
卷 21, 期 3, 页码 E148-E151出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clcc.2022.01.003
关键词
Ipilimumab after ipilimumab; Reinduction ipilimumab; Re-exposition ipilimumab; Ipilimumab-boost; MSI-H metastatic colorectal cancer
类别
This case report highlights the potential option of re-exposure to Ipilimumab as a strategy to restore immune-mediated disease control in patients with MSI-H mCRC who have had a long-lasting response to Ipilimumab/Nivolumab.
Background: Immune-Checkpoint-inhibitors (ICIs) are approved in first line therapy of microsatellite-instable, deficient miss-match-repair (MSI-H-dMMR) metastatic colorectal cancer (mCRC), and in second line after standard chemotherapy. Evidence supporting immunotherapy after immunotherapy is scarce.Case report: This case report highlights the course of a heavily pretreated patient with MSI-H mCRC with progression after multiple local therapies, standard chemotherapies and pembrolizumab. After 4 cycles of ipilimumab and nivolumab followed by nivolumab-maintenance he achieved a long-lasting disease control of 22 months. After further subsequent progression he regained immune mediated disease control by a second boost of ipilimumab. Conclusion: Re-exposition with ipilimumab is a potential option to restore immune-mediated-disease-control in patients with preceding long-lasting response to ipilimumab/nivolumab and with dMMR-tumors. The clinical situation of progress after long-lasting disease control on ICIs becomes more common and is an opportunity to investigate potential strategies for restoring immune mediated disease control. (C) 2022 Elsevier Inc. All rights reserved.
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